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Analysis of the effect of primaquine dose on efficacy, safety, and tolerability in patients with Plasmodium vivax malaria in Ethiopia: a systematic review and individual patient data meta-analysis.

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Title: Analysis of the effect of primaquine dose on efficacy, safety, and tolerability in patients with Plasmodium vivax malaria in Ethiopia: a systematic review and individual patient data meta-analysis.
Authors: Degaga TS; College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia. tamiru.degaga@menzies.edu.au.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. tamiru.degaga@menzies.edu.au., Thriemer K; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Rajasekhar M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Abreha T; ICAP, Columbia University Mailman, New York, USA., Assefa A; Malaria and Neglected Tropical Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.; Institute of Global Health, University of North Carolina at Chapel Hill, Chapel Hill, USA., Douglas NM; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Department of Medicine, University of Otago, Christchurch, New Zealand.; Department of Infectious Diseases, Christchurch Hospital, Te Whatu Ora, Christchurch, New Zealand., Gadisa E; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Hailu A; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Hwang J; Malaria Branch, Centers for Disease Control and Prevention, Atlanta, USA., Koh GCKW; Department of Infectious Diseases, Northwick Park Hospital, Middlesex, UK., Lacerda MVG; Fundação de Medicina Tropical Dr Heitor Vieira Dourado/Fiocruz, Manaus, Brazil., Llanos-Cuentas A; Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru., Mekonnen DA; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; College of Veterinary Medicine, Haramaya University, Haramaya, Ethiopia., Simpson JA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; WorldWide Antimalarial Resistance Network (WWARN), Asia Pacific Regional Centre, Melbourne, VIC, Australia., Tadesse FG; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Taylor WRJ; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., von Seidlein L; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Woyessa A; Malaria and Neglected Tropical Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.; Jimma University, Jimma, Ethiopia., Yeshiwondim AK; PATH Malaria Control and Elimination Partnership in Africa (MACEPA), Addis Ababa, Ethiopia., Yilma D; Jimma University, Jimma, Ethiopia., Price RN; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Bayissa GA; National Malaria and Other Vector-Borne Diseases Prevention and Control Desk Lead, Federal Ministry of Health, Addis Ababa, Ethiopia., Commons RJ; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; WorldWide Antimalarial Resistance Network (WWARN), Asia Pacific Regional Centre, Melbourne, VIC, Australia.; General and Subspecialty Medicine, Grampians Health-Ballarat, Ballarat, VIC, Australia.
Source: Malaria journal [Malar J] 2026 Jun 06. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
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  Data: Analysis of the effect of primaquine dose on efficacy, safety, and tolerability in patients with Plasmodium vivax malaria in Ethiopia: a systematic review and individual patient data meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Degaga+TS%22">Degaga TS</searchLink>; College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia. tamiru.degaga@menzies.edu.au.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. tamiru.degaga@menzies.edu.au.<br /><searchLink fieldCode="AU" term="%22Thriemer+K%22">Thriemer K</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Rajasekhar+M%22">Rajasekhar M</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Abreha+T%22">Abreha T</searchLink>; ICAP, Columbia University Mailman, New York, USA.<br /><searchLink fieldCode="AU" term="%22Assefa+A%22">Assefa A</searchLink>; Malaria and Neglected Tropical Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.; Institute of Global Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.<br /><searchLink fieldCode="AU" term="%22Douglas+NM%22">Douglas NM</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Department of Medicine, University of Otago, Christchurch, New Zealand.; Department of Infectious Diseases, Christchurch Hospital, Te Whatu Ora, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Gadisa+E%22">Gadisa E</searchLink>; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Hailu+A%22">Hailu A</searchLink>; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Hwang+J%22">Hwang J</searchLink>; Malaria Branch, Centers for Disease Control and Prevention, Atlanta, USA.<br /><searchLink fieldCode="AU" term="%22Koh+GCKW%22">Koh GCKW</searchLink>; Department of Infectious Diseases, Northwick Park Hospital, Middlesex, UK.<br /><searchLink fieldCode="AU" term="%22Lacerda+MVG%22">Lacerda MVG</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado/Fiocruz, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Llanos-Cuentas+A%22">Llanos-Cuentas A</searchLink>; Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Mekonnen+DA%22">Mekonnen DA</searchLink>; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; College of Veterinary Medicine, Haramaya University, Haramaya, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Simpson+JA%22">Simpson JA</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; WorldWide Antimalarial Resistance Network (WWARN), Asia Pacific Regional Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tadesse+FG%22">Tadesse FG</searchLink>; Malaria and Neglected Tropical Diseases Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Taylor+WRJ%22">Taylor WRJ</searchLink>; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22von+Seidlein+L%22">von Seidlein L</searchLink>; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Woyessa+A%22">Woyessa A</searchLink>; Malaria and Neglected Tropical Diseases Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.; Jimma University, Jimma, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Yeshiwondim+AK%22">Yeshiwondim AK</searchLink>; PATH Malaria Control and Elimination Partnership in Africa (MACEPA), Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Yilma+D%22">Yilma D</searchLink>; Jimma University, Jimma, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Price+RN%22">Price RN</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bayissa+GA%22">Bayissa GA</searchLink>; National Malaria and Other Vector-Borne Diseases Prevention and Control Desk Lead, Federal Ministry of Health, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Commons+RJ%22">Commons RJ</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.; WorldWide Antimalarial Resistance Network (WWARN), Asia Pacific Regional Centre, Melbourne, VIC, Australia.; General and Subspecialty Medicine, Grampians Health-Ballarat, Ballarat, VIC, Australia.
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