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Neuroprotection by lactate in Parkinson's disease: A novel anti-inflammatory mechanism via 14-3-3 protein lactylation.

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Title: Neuroprotection by lactate in Parkinson's disease: A novel anti-inflammatory mechanism via 14-3-3 protein lactylation.
Authors: Zhang Q; Institute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China., Liu M; The First Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China., Cao WJ; The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, 336 S Dongfeng Road, Hengyang, 421002, Hunan, PR China., Zou W; The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, 336 S Dongfeng Road, Hengyang, 421002, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China; Hengyang Key Laboratory of Parkinson's Disease Basic and Clinical Research (202150084071), Hengyang, 421001, Hunan, PR China., Zhang P; The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, 336 S Dongfeng Road, Hengyang, 421002, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China; Hengyang Key Laboratory of Parkinson's Disease Basic and Clinical Research (202150084071), Hengyang, 421001, Hunan, PR China., Tang YY; Institute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China. Electronic address: tangyy@usc.edu.cn., Tang XQ; Institute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China; The Second Affiliated Hospital, Brain Disease Research Institute of Neurological Medicine Center, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China. Electronic address: tangxq-usc@usc.edu.cn.
Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2026 Oct; Vol. 1872 (7), pp. 168314. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuroprotection by lactate in Parkinson's disease: A novel anti-inflammatory mechanism via 14-3-3 protein lactylation.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Institute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; The First Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China.<br /><searchLink fieldCode="AU" term="%22Cao+WJ%22">Cao WJ</searchLink>; The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, 336 S Dongfeng Road, Hengyang, 421002, Hunan, PR China.<br /><searchLink fieldCode="AU" term="%22Zou+W%22">Zou W</searchLink>; The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, 336 S Dongfeng Road, Hengyang, 421002, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China; Hengyang Key Laboratory of Parkinson's Disease Basic and Clinical Research (202150084071), Hengyang, 421001, Hunan, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; The Affiliated Nanhua Hospital, Department of Neurology, Hengyang Medical School, University of South China, 336 S Dongfeng Road, Hengyang, 421002, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China; Hengyang Key Laboratory of Parkinson's Disease Basic and Clinical Research (202150084071), Hengyang, 421001, Hunan, PR China.<br /><searchLink fieldCode="AU" term="%22Tang+YY%22">Tang YY</searchLink>; Institute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China. Electronic address: tangyy@usc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+XQ%22">Tang XQ</searchLink>; Institute of Neuroscience & Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China; NHC Key Laboratory of Neurodegenerative Disease (University of South China), Hengyang, 421001, Hunan, PR China; The Second Affiliated Hospital, Brain Disease Research Institute of Neurological Medicine Center, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, PR China. Electronic address: tangxq-usc@usc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101731730%22">Biochimica et biophysica acta. Molecular basis of disease</searchLink> [Biochim Biophys Acta Mol Basis Dis] 2026 Oct; Vol. 1872 (7), pp. 168314. <i>Date of Electronic Publication: </i>2026 Jun 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101731730 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-260X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209254439%22">09254439 </searchLink><i>NLM ISO Abbreviation: </i>Biochim Biophys Acta Mol Basis Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 Oct
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