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Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome.

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Title: Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome.
Authors: Posey JN; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States., Jordan M; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States., Olsen-Dufour A; School of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Nguyen TN; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Farrell C; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Lewis CV; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Archambault JL; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States., Sul C; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Colon-Hidalgo D; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.; School of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Nozik ES; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States., Espinosa JM; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz, Aurora CO, United States.; Department of Pharmacology, University of Colorado Anschutz, Aurora, CO, United States., Sullivan KD; Department of Pharmacology, University of Colorado Anschutz, Aurora, CO, United States.; Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States., Delaney C; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.
Source: Frontiers in immunology [Front Immunol] 2026 May 22; Vol. 17, pp. 1832057. Date of Electronic Publication: 2026 May 22 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Posey+JN%22">Posey JN</searchLink>; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Jordan+M%22">Jordan M</searchLink>; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Olsen-Dufour+A%22">Olsen-Dufour A</searchLink>; School of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+TN%22">Nguyen TN</searchLink>; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Farrell+C%22">Farrell C</searchLink>; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Lewis+CV%22">Lewis CV</searchLink>; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Archambault+JL%22">Archambault JL</searchLink>; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Sul+C%22">Sul C</searchLink>; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Colon-Hidalgo+D%22">Colon-Hidalgo D</searchLink>; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.; School of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Nozik+ES%22">Nozik ES</searchLink>; Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Espinosa+JM%22">Espinosa JM</searchLink>; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz, Aurora CO, United States.; Department of Pharmacology, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Sullivan+KD%22">Sullivan KD</searchLink>; Department of Pharmacology, University of Colorado Anschutz, Aurora, CO, United States.; Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Delaney+C%22">Delaney C</searchLink>; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz, Aurora, CO, United States.; Cardiovascular Pulmonary Research Laboratories, University of Colorado Anschutz, Aurora, CO, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 May 22; Vol. 17, pp. 1832057. <i>Date of Electronic Publication: </i>2026 May 22 (<i>Print Publication: </i>2026).
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