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Tau topography subtypes account for clinical heterogeneity and longitudinal trajectories in early-onset Alzheimer's disease.

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Title: Tau topography subtypes account for clinical heterogeneity and longitudinal trajectories in early-onset Alzheimer's disease.
Authors: Lin M; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Chiotis K; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Cognitive Disorders, Karolinska University Hospital, Stockholm, Sweden., Maiti P; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Zhang J; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Blazhenets G; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Rocha S; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Shankar R; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Amuiri A; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Hammers DB; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA., Eloyan A; Department of Biostatistics, Brown University, Providence, RI, USA., Kirby K; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA., Koeppe RA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA., Aisen P; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, USA., Beckett L; Department of Public Health Sciences, University of California Davis, Davis, CA, USA., Kukull WA; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Toga AW; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, CA, USA., Atri A; Banner Sun Health Research Institute, Sun City, AZ, USA., Clark DG; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA., Day GS; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Grant I; Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Honig LS; Taub Institute and Department of Neurology, Columbia University Irving Medical Center, NewYork, NY, USA., Johnson ECB; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Jones DT; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Masdeu JC; Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, TX, USA., Mendez MF; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Musiek E; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Onyike CU; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Riddle M; Department of Psychiatry, Alpert Medical School, Brown University, Providence, RI, USA., Rogalski E; Healthy Aging & Alzheimer's Research Care Center, Department of Neurology, University of Chicago, Chicago, IL, USA., Salloway S; Department of Psychiatry, Alpert Medical School, Brown University, Providence, RI, USA., Sha SJ; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA., Turner RS; Department of Neurology, Georgetown University, Washington, DC, USA., Wingo TS; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Wolk DA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Womack KB; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Nudelman KNH; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Touroutoglou A; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Vogel JW; Department of Clinical Sciences Malmö, Faculty of Medicine, SciLifeLab, Lund University, Lund, Sweden., Dufault SM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Hoffmann TJ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Carrillo MC; Medical & Scientific Relations Division, Alzheimer's Association, Chicago, IL, USA., Dickerson BC; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Apostolova LG; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA., Rabinovici GD; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA., La Joie R; Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Source: Brain communications [Brain Commun] 2026 May 18; Vol. 8 (3), pp. fcag176. Date of Electronic Publication: 2026 May 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE
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