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HBsAg loss in chronic hepatitis B patients with an HBsAg decline plateau can be enhanced by intermittent PEG-IFN treatment.

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Title: HBsAg loss in chronic hepatitis B patients with an HBsAg decline plateau can be enhanced by intermittent PEG-IFN treatment.
Authors: Cao W; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Xie S; Division of Hepatology, Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China., Hao H; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Deng W; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Zhang L; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Lu Y; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Liu R; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Wang S; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Li X; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Zhang Z; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Wei X; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Gao Z; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Yao L; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Wang S; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Gao Y; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Wang Y; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Xu M; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Hu L; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Xie Y; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China., Li M; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China.
Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 May 21; Vol. 16, pp. 1778016. Date of Electronic Publication: 2026 May 21 (Print Publication: 2026).
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HBsAg loss in chronic hepatitis B patients with an HBsAg decline plateau can be enhanced by intermittent PEG-IFN treatment.
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  Data: <searchLink fieldCode="AU" term="%22Cao+W%22">Cao W</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xie+S%22">Xie S</searchLink>; Division of Hepatology, Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hao+H%22">Hao H</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Deng+W%22">Deng W</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gao+Z%22">Gao Z</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yao+L%22">Yao L</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink>; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.; 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  Data: <searchLink fieldCode="JN" term="%22101585359%22">Frontiers in cellular and infection microbiology</searchLink> [Front Cell Infect Microbiol] 2026 May 21; Vol. 16, pp. 1778016. <i>Date of Electronic Publication: </i>2026 May 21 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+SA%22">Frontiers Media SA </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101585359 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2235-2988 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222352988%22">22352988 </searchLink><i>NLM ISO Abbreviation: </i>Front Cell Infect Microbiol <i>Subsets: </i>MEDLINE
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