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Temporal transcriptomic profiling identifies core regulators in cytokine-induced gut barrier disruption in differentiated Caco-2 cells.

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Title: Temporal transcriptomic profiling identifies core regulators in cytokine-induced gut barrier disruption in differentiated Caco-2 cells.
Authors: Yoon HS; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA.; Amgen R&D Postdoctoral Fellows Program, South San Francisco, CA, 94080, USA., Ma S; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Kanke M; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Wu WJ; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA., Hoang U; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Tan JA; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Wilks A; Translational Safety & Risk Sciences, Amgen Research, South San Francisco, CA, 94080, USA., Patel P; Translational Safety & Risk Sciences, Amgen Research, South San Francisco, CA, 94080, USA., Chandra S; Translational Safety & Risk Sciences, Amgen Research, South San Francisco, CA, 94080, USA., Luo X; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Lu D; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Martin S; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Wilson M; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA., Van Lookeren Campagne M; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA., Li CM; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA., Kao CY; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA. ckao01@amgen.com.
Source: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2026 Jun 08; Vol. 75 (1). Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9508160 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-908X (Electronic) Linking ISSN: 10233830 NLM ISO Abbreviation: Inflamm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Temporal transcriptomic profiling identifies core regulators in cytokine-induced gut barrier disruption in differentiated Caco-2 cells.
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  Data: <searchLink fieldCode="AU" term="%22Yoon+HS%22">Yoon HS</searchLink>; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA.; Amgen R&D Postdoctoral Fellows Program, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ma+S%22">Ma S</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Kanke+M%22">Kanke M</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wu+WJ%22">Wu WJ</searchLink>; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+U%22">Hoang U</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Tan+JA%22">Tan JA</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wilks+A%22">Wilks A</searchLink>; Translational Safety & Risk Sciences, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Translational Safety & Risk Sciences, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chandra+S%22">Chandra S</searchLink>; Translational Safety & Risk Sciences, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Luo+X%22">Luo X</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lu+D%22">Lu D</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Martin+S%22">Martin S</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+M%22">Wilson M</searchLink>; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Van+Lookeren+Campagne+M%22">Van Lookeren Campagne M</searchLink>; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Li+CM%22">Li CM</searchLink>; Discovery Sciences, Advanced Technologies, & AI, Amgen Research, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Kao+CY%22">Kao CY</searchLink>; Inflammation Therapeutic Area, Amgen Research, South San Francisco, CA, 94080, USA. ckao01@amgen.com.
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  Data: <searchLink fieldCode="JN" term="%229508160%22">Inflammation research : official journal of the European Histamine Research Society ... [et al.]</searchLink> [Inflamm Res] 2026 Jun 08; Vol. 75 (1). <i>Date of Electronic Publication: </i>2026 Jun 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Birkhäuser%22">Birkhäuser </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9508160 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-908X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210233830%22">10233830 </searchLink><i>NLM ISO Abbreviation: </i>Inflamm Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00011-026-02288-5
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              Text: 2026 Jun 08
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