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The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages.

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Title: The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages.
Authors: Circu M; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America., Castore R; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America., Latimer B; Innovative North Louisiana Experimental Therapeutics program (INLET), Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America., Shames S; Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan, United States of America., Roy CR; Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut, United States of America., Dragoi AM; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.; Innovative North Louisiana Experimental Therapeutics program (INLET), Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America., Ivanov SS; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2026 Jun 08; Vol. 22 (6), pp. e1012998. Date of Electronic Publication: 2026 Jun 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages.
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  Data: <searchLink fieldCode="AU" term="%22Circu+M%22">Circu M</searchLink>; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Castore+R%22">Castore R</searchLink>; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Latimer+B%22">Latimer B</searchLink>; Innovative North Louisiana Experimental Therapeutics program (INLET), Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Shames+S%22">Shames S</searchLink>; Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan, United States of America.<br /><searchLink fieldCode="AU" term="%22Roy+CR%22">Roy CR</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Dragoi+AM%22">Dragoi AM</searchLink>; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.; Innovative North Louisiana Experimental Therapeutics program (INLET), Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Ivanov+SS%22">Ivanov SS</searchLink>; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States of America.
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      – TitleFull: The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages.
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              Text: 2026 Jun 08
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