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Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.

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Title: Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.
Authors: Pines AR; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305., Zhang X; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305., Kochalka J; Department of Bioengineering, Stanford University, Palo Alto, CA 94305., Vesuna SS; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.; Department of Bioengineering, Stanford University, Palo Alto, CA 94305., Kauvar IV; Department of Bioengineering, Stanford University, Palo Alto, CA 94305.; Department of Education, Graduate School of Education, Stanford University, Palo Alto, CA 94305., Rajasekharan D; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305., Reneau TR; Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110., Akiki TJ; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305., Hack LM; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.; Sierra-Pacific Mental Illness Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304., Siegel JS; Department of Psychiatry, New York University, Langone Center for Psychedelic Medicine, New York University Grossman School of Medicine, New York, NY 10016.; Nathan Kline Institute for Psychiatric Research, New York, NY 10962., Williams LM; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.; Sierra-Pacific Mental Illness Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 16; Vol. 123 (24), pp. e2522000123. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.
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  Data: <searchLink fieldCode="AU" term="%22Pines+AR%22">Pines AR</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Kochalka+J%22">Kochalka J</searchLink>; Department of Bioengineering, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Vesuna+SS%22">Vesuna SS</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.; Department of Bioengineering, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Kauvar+IV%22">Kauvar IV</searchLink>; Department of Bioengineering, Stanford University, Palo Alto, CA 94305.; Department of Education, Graduate School of Education, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Rajasekharan+D%22">Rajasekharan D</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Reneau+TR%22">Reneau TR</searchLink>; Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.<br /><searchLink fieldCode="AU" term="%22Akiki+TJ%22">Akiki TJ</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.<br /><searchLink fieldCode="AU" term="%22Hack+LM%22">Hack LM</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.; Sierra-Pacific Mental Illness Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.<br /><searchLink fieldCode="AU" term="%22Siegel+JS%22">Siegel JS</searchLink>; Department of Psychiatry, New York University, Langone Center for Psychedelic Medicine, New York University Grossman School of Medicine, New York, NY 10016.; Nathan Kline Institute for Psychiatric Research, New York, NY 10962.<br /><searchLink fieldCode="AU" term="%22Williams+LM%22">Williams LM</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305.; Sierra-Pacific Mental Illness Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jun 16; Vol. 123 (24), pp. e2522000123. <i>Date of Electronic Publication: </i>2026 Jun 08.
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