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Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model.

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Title: Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model.
Authors: Kesharwani A; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33458.; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; David and Lynn Nicholson Center for Neuroscience Research, Jupiter, FL 33458., Dagar S; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33458.; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; David and Lynn Nicholson Center for Neuroscience Research, Jupiter, FL 33458., Zuniga I; FAU Honors College, Jupiter, FL 33458., Monet MC; The International Max Planck Research School for Synapses and Circuits, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458.; Department of Biological Sciences, Charles E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL 33431., Halade G; Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Tampa, FL 33602.; Hypertension and Kidney Research Center, Heart Institute, University of South Florida, Tampa, FL 33602., Upadhyay G; Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Tampa, FL 33602., Nimrod Ramírez-Jarquín U; National Institute of Cardiology Ignacio Chavez, Mexico City 14080, Mexico., Gisselle Lopez-Huerta V; Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City 04510, Mexico., Mirza E; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458., Quan N; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431., Subramaniam S; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33458.; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; David and Lynn Nicholson Center for Neuroscience Research, Jupiter, FL 33458.; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431.; Center for Molecular Biology and Biotechnology, Jupiter, FL 33458.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 16; Vol. 123 (24), pp. e2535879123. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kesharwani+A%22">Kesharwani A</searchLink>; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33458.; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; David and Lynn Nicholson Center for Neuroscience Research, Jupiter, FL 33458.<br /><searchLink fieldCode="AU" term="%22Dagar+S%22">Dagar S</searchLink>; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33458.; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; David and Lynn Nicholson Center for Neuroscience Research, Jupiter, FL 33458.<br /><searchLink fieldCode="AU" term="%22Zuniga+I%22">Zuniga I</searchLink>; FAU Honors College, Jupiter, FL 33458.<br /><searchLink fieldCode="AU" term="%22Monet+MC%22">Monet MC</searchLink>; The International Max Planck Research School for Synapses and Circuits, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458.; Department of Biological Sciences, Charles E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL 33431.<br /><searchLink fieldCode="AU" term="%22Halade+G%22">Halade G</searchLink>; Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Tampa, FL 33602.; Hypertension and Kidney Research Center, Heart Institute, University of South Florida, Tampa, FL 33602.<br /><searchLink fieldCode="AU" term="%22Upadhyay+G%22">Upadhyay G</searchLink>; Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, University of South Florida, Tampa, FL 33602.<br /><searchLink fieldCode="AU" term="%22Nimrod+Ramírez-Jarquín+U%22">Nimrod Ramírez-Jarquín U</searchLink>; National Institute of Cardiology Ignacio Chavez, Mexico City 14080, Mexico.<br /><searchLink fieldCode="AU" term="%22Gisselle+Lopez-Huerta+V%22">Gisselle Lopez-Huerta V</searchLink>; Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City 04510, Mexico.<br /><searchLink fieldCode="AU" term="%22Mirza+E%22">Mirza E</searchLink>; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.<br /><searchLink fieldCode="AU" term="%22Quan+N%22">Quan N</searchLink>; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431.<br /><searchLink fieldCode="AU" term="%22Subramaniam+S%22">Subramaniam S</searchLink>; Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL 33458.; Florida Atlantic University, Stiles-Nicholson Brain Institute, Jupiter, FL 33458.; David and Lynn Nicholson Center for Neuroscience Research, Jupiter, FL 33458.; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431.; Center for Molecular Biology and Biotechnology, Jupiter, FL 33458.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jun 16; Vol. 123 (24), pp. e2535879123. <i>Date of Electronic Publication: </i>2026 Jun 08.
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