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mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model.

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Title: mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model.
Authors: Skelly AN; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Fan C; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Ökten AB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06510.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510., Gavor E; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Newby ML; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom., Allen JD; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom., Kreider EF; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Ding W; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Osbaldeston RA; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Park Y; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Connell AJ; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Lituchy MG; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Bibollet-Ruche F; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Radford KM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., P West A Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Peña-Hernández MA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06510.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510., Cruickshank K; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Liu W; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Li Y; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Albertus A; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., McWilliams B; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Russell RM; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Konrath KM; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Gao H; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710.; Department of Surgery, Duke University Medical Center, Durham, NC 27710., Montefiori DC; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710.; Department of Surgery, Duke University Medical Center, Durham, NC 27710., Saag MS; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233., Goepfert PA; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233.; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35233.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233., Kulp DW; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Shaw GM; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104., Andrabi R; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom., Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Wilen CB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06510.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Hahn BH; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 16; Vol. 123 (24), pp. e2536870123. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model.
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