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Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling.

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Title: Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling.
Authors: Liang Z; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Long X; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Xiong Z; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Wong PP; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Huang S; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Chen S; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Zhang Y; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Zhang L; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Leung C; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China., Cao J; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Wu H; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Yue H; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Zhao Z; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Tu Y; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Yin B; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Yang W; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Wang J; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Chen S; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Zhang X; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Tsang YW; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Zhong C; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China., Liu X; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Ding L; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Lu J; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Si-Tou WW; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Liu Y; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Wang Y; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Lin Y; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Liang J; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Ren W; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Vong JS; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Tong M; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Tian X; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Hui HX; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Zhou J; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Ngai S; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China., Ni S; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China., To KF; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China., Braun T; Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany., Jao-Yiu Sung J; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China., Chan SL; Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: chanlam_stephen@cuhk.edu.hk., Cheng AS; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: alfredcheng@cuhk.edu.hk.
Source: Cancer cell [Cancer Cell] 2026 Jun 08; Vol. 44 (6), pp. 1235-1254.e11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling.
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School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ngai+S%22">Ngai S</searchLink>; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ni+S%22">Ni S</searchLink>; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22To+KF%22">To KF</searchLink>; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Braun+T%22">Braun T</searchLink>; Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Jao-Yiu+Sung+J%22">Jao-Yiu Sung J</searchLink>; 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