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Efficacy of chloroquine plus low-dose primaquine and pyronaridine-artesunate plus low-dose primaquine against Plasmodium vivax malaria in adults and transmission to mosquitoes in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.

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Title: Efficacy of chloroquine plus low-dose primaquine and pyronaridine-artesunate plus low-dose primaquine against Plasmodium vivax malaria in adults and transmission to mosquitoes in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.
Authors: Bezabih MK; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Sisay S; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Behaksera SW; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Ramjith J; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Teka H; US President's Malaria Initiative, USAID, Addis Ababa, Ethiopia., Girma S; US President's Malaria Initiative, USAID, Addis Ababa, Ethiopia., Shimelash A; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Ejigu LA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Kassa FA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Hailegiorgis B; ICAP at Columbia University, Addis Ababa, Ethiopia., Tadesse M; ICAP at Columbia University, Addis Ababa, Ethiopia., Misganaw T; Woldia University, Woldia, Ethiopia., Gizat A; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Gashaw A; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Habtamu G; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Legesse NS; ICAP at Columbia University, Addis Ababa, Ethiopia., Hundera NL; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Milki DW; ICAP at Columbia University, Addis Ababa, Ethiopia., Abdo M; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Chali W; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Tongren JE; US President's Malaria Initiative, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Hwang J; US President's Malaria Initiative, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Bousema T; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Tadesse FG; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: fitsum.girma@ahri.gov.et.
Source: The Lancet. Microbe [Lancet Microbe] 2026 Dec 31, pp. 101342. Date of Electronic Publication: 2026 Dec 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
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  Data: Efficacy of chloroquine plus low-dose primaquine and pyronaridine-artesunate plus low-dose primaquine against Plasmodium vivax malaria in adults and transmission to mosquitoes in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.
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  Data: <searchLink fieldCode="AU" term="%22Bezabih+MK%22">Bezabih MK</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sisay+S%22">Sisay S</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Behaksera+SW%22">Behaksera SW</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Ramjith+J%22">Ramjith J</searchLink>; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Teka+H%22">Teka H</searchLink>; US President's Malaria Initiative, USAID, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Girma+S%22">Girma S</searchLink>; US President's Malaria Initiative, USAID, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Shimelash+A%22">Shimelash A</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Ejigu+LA%22">Ejigu LA</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Kassa+FA%22">Kassa FA</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Hailegiorgis+B%22">Hailegiorgis B</searchLink>; ICAP at Columbia University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Tadesse+M%22">Tadesse M</searchLink>; ICAP at Columbia University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Misganaw+T%22">Misganaw T</searchLink>; Woldia University, Woldia, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Gizat+A%22">Gizat A</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Gashaw+A%22">Gashaw A</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Habtamu+G%22">Habtamu G</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Legesse+NS%22">Legesse NS</searchLink>; ICAP at Columbia University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Hundera+NL%22">Hundera NL</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Milki+DW%22">Milki DW</searchLink>; ICAP at Columbia University, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Abdo+M%22">Abdo M</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Chali+W%22">Chali W</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tongren+JE%22">Tongren JE</searchLink>; US President's Malaria Initiative, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+J%22">Hwang J</searchLink>; US President's Malaria Initiative, US Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bousema+T%22">Bousema T</searchLink>; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tadesse+FG%22">Tadesse FG</searchLink>; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: fitsum.girma@ahri.gov.et.
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  Data: <searchLink fieldCode="JN" term="%22101769019%22">The Lancet. Microbe</searchLink> [Lancet Microbe] 2026 Dec 31, pp. 101342. <i>Date of Electronic Publication: </i>2026 Dec 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101769019 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-5247 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226665247%22">26665247 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Microbe <i>Subsets: </i>MEDLINE
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