Evaluation of the effectiveness of artemether-lumefantrine and artesunate-pyronaridine each combined with single low-dose primaquine in adults with Plasmodium falciparum infection in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial.
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| Title: | Evaluation of the effectiveness of artemether-lumefantrine and artesunate-pyronaridine each combined with single low-dose primaquine in adults with Plasmodium falciparum infection in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial. |
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| Authors: | Bezabih MK; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Misganaw T; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia., Ejigu LA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Rosillo S; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Teka H; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia., Alemayehu DH; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Adnew B; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Hailegiorgis B; US President's Malaria Initiative Malaria Laboratory Diagnosis and Treatment Activity, International Center for AIDS Care and Treatment Programs at Columbia University, Addis Ababa, Ethiopia., Girma S; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia., Tadesse M; US President's Malaria Initiative Malaria Laboratory Diagnosis and Treatment Activity, International Center for AIDS Care and Treatment Programs at Columbia University, Addis Ababa, Ethiopia., Kassa FA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Gebremichael M; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Tefera DA; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Chali W; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Behaksera SW; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Alemayehu L; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Deressa JD; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Abdo M; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Habtamu G; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Gizat A; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Yalew WG; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia., Jember TH; Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia., Bitew M; Bio and Emerging Technology Institute, Addis Ababa, Ethiopia., Mumba P; US President's Malaria Initiative, US Agency for International Development (USAID), Addis Ababa, Ethiopia., Plucinski MM; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Souza S; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Patel DS; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Talundzic E; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Taffese HS; Ministry of Health, Addis Ababa, Ethiopia., Geleta KE; Ministry of Health, Addis Ababa, Ethiopia., Mehari D; Ministry of Health, Addis Ababa, Ethiopia., Bayissa GA; Ministry of Health, Addis Ababa, Ethiopia., Bousema T; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands., Tongren JE; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Hwang J; US President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Tadesse FG; Malaria and NTD Division, Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: fitsum.girma@ahri.gov.et. |
| Source: | The Lancet. Microbe [Lancet Microbe] 2026 Dec 18, pp. 101344. Date of Electronic Publication: 2026 Dec 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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