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5' leader defects drive persistent HIV-1 viremia on long-term ART.

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Title: 5' leader defects drive persistent HIV-1 viremia on long-term ART.
Authors: Box JR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Camilo-Contreras A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Dragoni F; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yue FY; Department of Medicine, University of Toronto, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada., Matveev V; Department of Medicine, University of Toronto, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada., Foley J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhang J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mok YW; Maple Leaf Medical Clinic, Toronto, Ontario, Canada., DeSousa M; Maple Leaf Medical Clinic, Toronto, Ontario, Canada., Lai J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mulcare Z; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bakewell Z; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Poulin S; Clinique L'Agora, Montréal, Québec, Canada., Chano F; Clinique L'Agora, Montréal, Québec, Canada., Fortin C; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.; Département de Microbiologie, Immunologie et Infectiologie, Université de Montréal, Montréal, Québec, Canada., Tremblay C; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.; Département de Microbiologie, Immunologie et Infectiologie, Université de Montréal, Montréal, Québec, Canada., Blankson JN; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Krishnan S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Weld ED; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Basseth C; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hamill MM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hoffmann CJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Scully EP; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Jones JL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cox AL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., El Atrouni W; Division of Infectious Diseases, The University of Kansas Medical Center, Kansas City, KS, USA., Sha B; Rush University Medical Center, Division of Infectious Diseases, Chicago, IL, USA., Siliciano JD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Baltimore, MD, USA., Reinhard R; San Francisco, CA, USA., Gunst JD; Aarhus University, Department of Clinical Medicine, Aarhus, Denmark.; Aarhus University Hospital, Department of Infectious Diseases, Aarhus, Denmark., Ostrowski M; Department of Medicine, University of Toronto, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada., Maldarelli F; National Cancer Institute, Frederick, MD, USA., Kovacs C; Department of Medicine, University of Toronto, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.; Maple Leaf Medical Clinic, Toronto, Ontario, Canada., Simonetti FR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. fsimonetti@jhmi.edu.
Source: Nature communications [Nat Commun] 2026 Jun 08; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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