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Mechanistic investigation of the hepatotoxicity and potential carcinogenicity of microcystin-LR, -LA, and -RR in the HepaRG cell line model.

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Title: Mechanistic investigation of the hepatotoxicity and potential carcinogenicity of microcystin-LR, -LA, and -RR in the HepaRG cell line model.
Authors: Silva EZM; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Kiessig S; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Suciu I; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Mathias C; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil., de Lourdes Marzo-Solano M; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Pestana CB; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil., Marx-Stoelting P; German Federal Institute for Risk Assessment (BfR), Berlin, Germany. Philip.Marx-Stoelting@bfr.bund.de., Leme DM; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Source: Archives of toxicology [Arch Toxicol] 2026 Jun 08. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mechanistic investigation of the hepatotoxicity and potential carcinogenicity of microcystin-LR, -LA, and -RR in the HepaRG cell line model.
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  Data: <searchLink fieldCode="AU" term="%22Silva+EZM%22">Silva EZM</searchLink>; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kiessig+S%22">Kiessig S</searchLink>; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Suciu+I%22">Suciu I</searchLink>; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mathias+C%22">Mathias C</searchLink>; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Lourdes+Marzo-Solano+M%22">de Lourdes Marzo-Solano M</searchLink>; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pestana+CB%22">Pestana CB</searchLink>; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Marx-Stoelting+P%22">Marx-Stoelting P</searchLink>; German Federal Institute for Risk Assessment (BfR), Berlin, Germany. Philip.Marx-Stoelting@bfr.bund.de.<br /><searchLink fieldCode="AU" term="%22Leme+DM%22">Leme DM</searchLink>; Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
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        Value: 10.1007/s00204-026-04458-0
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        Text: English
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      – TitleFull: Mechanistic investigation of the hepatotoxicity and potential carcinogenicity of microcystin-LR, -LA, and -RR in the HepaRG cell line model.
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            NameFull: Silva EZM
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            – D: 08
              M: 06
              Text: 2026 Jun 08
              Type: published
              Y: 2026
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