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Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10.

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Title: Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10.
Authors: Novita R; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, 16911, Indonesia., Fathoni A; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, 16911, Indonesia., Waluyo D; Research Center for Vaccine and Drug, National Research and Innovation Agency (BRIN), KST Soekarno, Jl Raya Jakarta - Bogor Km. 46, Cibinong, 16911, Indonesia., Suprayogi A; Department of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Jl. Agatis, Dramaga, Bogor, 16680, Indonesia., Darusman HS; Primate Research Center, IPB University, Jl. Lodaya II/5, Bogor, 16151, Indonesia., Nugraha AB; Division of Parasitology and Medical Entomology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Jl. Agatis, Dramaga, Bogor, 16680, Indonesia., Nurkanto A; Research Center for Biosystematics and Evolution, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor Km. 46, Cibinong, 16911, Indonesia., Ilmi H; Doctoral Program of the Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, Indonesia., Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan., Agusta A; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, 16911, Indonesia. andr005@brin.go.id.
Source: Malaria journal [Malar J] 2026 Jun 08; Vol. 25 (1). Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
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  Data: Exploring the antimalarial potential of (+)-2,2'-epicytoskyrin A: in vitro and in vivo studies of a bioactive metabolite from endophytic fungus Diaporthe sp. GNBP-10.
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  Data: <searchLink fieldCode="AU" term="%22Novita+R%22">Novita R</searchLink>; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, 16911, Indonesia.<br /><searchLink fieldCode="AU" term="%22Fathoni+A%22">Fathoni A</searchLink>; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, 16911, Indonesia.<br /><searchLink fieldCode="AU" term="%22Waluyo+D%22">Waluyo D</searchLink>; Research Center for Vaccine and Drug, National Research and Innovation Agency (BRIN), KST Soekarno, Jl Raya Jakarta - Bogor Km. 46, Cibinong, 16911, Indonesia.<br /><searchLink fieldCode="AU" term="%22Suprayogi+A%22">Suprayogi A</searchLink>; Department of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Jl. Agatis, Dramaga, Bogor, 16680, Indonesia.<br /><searchLink fieldCode="AU" term="%22Darusman+HS%22">Darusman HS</searchLink>; Primate Research Center, IPB University, Jl. Lodaya II/5, Bogor, 16151, Indonesia.<br /><searchLink fieldCode="AU" term="%22Nugraha+AB%22">Nugraha AB</searchLink>; Division of Parasitology and Medical Entomology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Jl. Agatis, Dramaga, Bogor, 16680, Indonesia.<br /><searchLink fieldCode="AU" term="%22Nurkanto+A%22">Nurkanto A</searchLink>; Research Center for Biosystematics and Evolution, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor Km. 46, Cibinong, 16911, Indonesia.<br /><searchLink fieldCode="AU" term="%22Ilmi+H%22">Ilmi H</searchLink>; Doctoral Program of the Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, Indonesia.<br /><searchLink fieldCode="AU" term="%22Nozaki+T%22">Nozaki T</searchLink>; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Agusta+A%22">Agusta A</searchLink>; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Jl. Raya Jakarta - Bogor KM. 46, Cibinong, 16911, Indonesia. andr005@brin.go.id.
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  Data: <searchLink fieldCode="JN" term="%22101139802%22">Malaria journal</searchLink> [Malar J] 2026 Jun 08; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 Jun 08.
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        Value: 10.1186/s12936-026-05972-3
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              Text: 2026 Jun 08
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