Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype.
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| Title: | Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype. |
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| Authors: | Lindell RB; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sayed SU; Division of Allergy and Immunology, Department of Pediatrics., Campos Duran JS; Division of Allergy and Immunology, Department of Pediatrics., Sheetz SA; Division of Allergy and Immunology, Department of Pediatrics.; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, and., Babu A; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Knight MS; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Mauracher AA; Division of Allergy and Immunology, Department of Pediatrics., Hay CA; Division of Allergy and Immunology, Department of Pediatrics., Conrey PE; Division of Allergy and Immunology, Department of Pediatrics., Fitzgerald JC; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Yehya N; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Famularo ST 3rd; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, and., Arroyo T; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, and., Tustin R 3rd; Division of Allergy and Immunology, Department of Pediatrics., Fazelinia H; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Behrens EM; Division of Rheumatology, Department of Pediatrics and., Teachey DT; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Forbes Satter LR; Division of Immunology, Allergy, and Retrovirology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA., Freeman AF; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA., Bergerson JR; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA., Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA., Leiding JW; Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine and Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA., Weiss SL; Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, Delaware, USA., Hall MW; Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA., Taylor DM; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics., Feng R; Department of Biostatistics, Epidemiology, and Informatics., Wherry EJ; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Systems Pharmacology and Translational Therapeutics, and., Meyer NJ; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Henrickson SE; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2026 Jun 09; Vol. 136 (14). Date of Electronic Publication: 2026 Jun 09 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42262868 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lindell+RB%22">Lindell RB</searchLink>; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sayed+SU%22">Sayed SU</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Campos+Duran+JS%22">Campos Duran JS</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Sheetz+SA%22">Sheetz SA</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, and.<br /><searchLink fieldCode="AU" term="%22Babu+A%22">Babu A</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Knight+MS%22">Knight MS</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mauracher+AA%22">Mauracher AA</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Hay+CA%22">Hay CA</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Conrey+PE%22">Conrey PE</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+JC%22">Fitzgerald JC</searchLink>; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Yehya+N%22">Yehya N</searchLink>; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Famularo+ST+3rd%22">Famularo ST 3rd</searchLink>; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, and.<br /><searchLink fieldCode="AU" term="%22Arroyo+T%22">Arroyo T</searchLink>; Division of Critical Care Medicine, Department of Anesthesia and Critical Care, and.<br /><searchLink fieldCode="AU" term="%22Tustin+R+3rd%22">Tustin R 3rd</searchLink>; Division of Allergy and Immunology, Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Fazelinia+H%22">Fazelinia H</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Behrens+EM%22">Behrens EM</searchLink>; Division of Rheumatology, Department of Pediatrics and.<br /><searchLink fieldCode="AU" term="%22Teachey+DT%22">Teachey DT</searchLink>; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Forbes+Satter+LR%22">Forbes Satter LR</searchLink>; Division of Immunology, Allergy, and Retrovirology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+AF%22">Freeman AF</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bergerson+JR%22">Bergerson JR</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Holland+SM%22">Holland SM</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Leiding+JW%22">Leiding JW</searchLink>; Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine and Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+SL%22">Weiss SL</searchLink>; Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Hall+MW%22">Hall MW</searchLink>; Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+DM%22">Taylor DM</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics.<br /><searchLink fieldCode="AU" term="%22Feng+R%22">Feng R</searchLink>; Department of Biostatistics, Epidemiology, and Informatics.<br /><searchLink fieldCode="AU" term="%22Wherry+EJ%22">Wherry EJ</searchLink>; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Systems Pharmacology and Translational Therapeutics, and.<br /><searchLink fieldCode="AU" term="%22Meyer+NJ%22">Meyer NJ</searchLink>; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Henrickson+SE%22">Henrickson SE</searchLink>; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Jun 09; Vol. 136 (14). <i>Date of Electronic Publication: </i>2026 Jun 09 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1172/JCI202867 Languages: – Code: eng Text: English Titles: – TitleFull: Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lindell RB – PersonEntity: Name: NameFull: Sayed SU – PersonEntity: Name: NameFull: Campos Duran JS – PersonEntity: Name: NameFull: Sheetz SA – PersonEntity: Name: NameFull: Babu A – PersonEntity: Name: NameFull: Knight MS – PersonEntity: Name: NameFull: Mauracher AA – PersonEntity: Name: NameFull: Hay CA – PersonEntity: Name: NameFull: Conrey PE – PersonEntity: Name: NameFull: Fitzgerald JC – PersonEntity: Name: NameFull: Yehya N – PersonEntity: Name: NameFull: Famularo ST 3rd – PersonEntity: Name: NameFull: Arroyo T – PersonEntity: Name: NameFull: Tustin R 3rd – PersonEntity: Name: NameFull: Fazelinia H – PersonEntity: Name: NameFull: Behrens EM – PersonEntity: Name: NameFull: Teachey DT – PersonEntity: Name: NameFull: Forbes Satter LR – PersonEntity: Name: NameFull: Freeman AF – PersonEntity: Name: NameFull: Bergerson JR – PersonEntity: Name: NameFull: Holland SM – PersonEntity: Name: NameFull: Leiding JW – PersonEntity: Name: NameFull: Weiss SL – PersonEntity: Name: NameFull: Hall MW – PersonEntity: Name: NameFull: Taylor DM – PersonEntity: Name: NameFull: Feng R – PersonEntity: Name: NameFull: Wherry EJ – PersonEntity: Name: NameFull: Meyer NJ – PersonEntity: Name: NameFull: Henrickson SE IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 06 Text: 2026 Jun 09 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1558-8238 Numbering: – Type: volume Value: 136 – Type: issue Value: 14 Titles: – TitleFull: The Journal of clinical investigation Type: main |
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