APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection.

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Title: APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection.
Authors: Pell J; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Tanvir EM; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Sun Z; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America., Chernova I; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Reghuvaran A; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Nagata S; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Guerra MT; Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States of America., Choi J; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America., Al Chaar S; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America., Mizuno H; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America., Dong K; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Tian X; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Ishibe R; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Franchin B; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America., Cravedi P; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America., Kumar A; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Barsotti G; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Shi H; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., De Kumar B; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Smithson S; Division of Nephrology, Washington University, St. Louis, United States of America., Song W; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., He JC; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America., Chong AS; Department of Surgery, The University of Chicago, Chicago, United States of America., Pober JS; Department of Immunobiology, Yale University School of Medicine, New Haven, United States of America., Somlo S; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Gibson IW; Department of Pathology, University of Manitoba, Winnipeg, Canada., Popik W; Center for AIDS Health Disparities Research, Department of Internal Medicin, Meharry Medical College, Nashville, United States of America., Zhang Z; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America., Craft J; Department of Immunobiology, Yale University School of Medicine, New Haven, United States of America., Azzi J; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America., Murakami N; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America., Ishibe S; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America., Heeger PS; Cedars-Sinai Medical Center, Los Angeles, United States of America., Menon MC; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
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  Data: APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection.
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  Data: <searchLink fieldCode="AU" term="%22Pell+J%22">Pell J</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Tanvir+EM%22">Tanvir EM</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Chernova+I%22">Chernova I</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Reghuvaran+A%22">Reghuvaran A</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Nagata+S%22">Nagata S</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Guerra+MT%22">Guerra MT</searchLink>; Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America.<br /><searchLink fieldCode="AU" term="%22Al+Chaar+S%22">Al Chaar S</searchLink>; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America.<br /><searchLink fieldCode="AU" term="%22Mizuno+H%22">Mizuno H</searchLink>; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America.<br /><searchLink fieldCode="AU" term="%22Dong+K%22">Dong K</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Ishibe+R%22">Ishibe R</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Franchin+B%22">Franchin B</searchLink>; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Cravedi+P%22">Cravedi P</searchLink>; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Barsotti+G%22">Barsotti G</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22De+Kumar+B%22">De Kumar B</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Smithson+S%22">Smithson S</searchLink>; Division of Nephrology, Washington University, St. Louis, United States of America.<br /><searchLink fieldCode="AU" term="%22Song+W%22">Song W</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22He+JC%22">He JC</searchLink>; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Chong+AS%22">Chong AS</searchLink>; Department of Surgery, The University of Chicago, Chicago, United States of America.<br /><searchLink fieldCode="AU" term="%22Pober+JS%22">Pober JS</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Somlo+S%22">Somlo S</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Gibson+IW%22">Gibson IW</searchLink>; Department of Pathology, University of Manitoba, Winnipeg, Canada.<br /><searchLink fieldCode="AU" term="%22Popik+W%22">Popik W</searchLink>; Center for AIDS Health Disparities Research, Department of Internal Medicin, Meharry Medical College, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Craft+J%22">Craft J</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Azzi+J%22">Azzi J</searchLink>; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America.<br /><searchLink fieldCode="AU" term="%22Murakami+N%22">Murakami N</searchLink>; Transplant Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America.<br /><searchLink fieldCode="AU" term="%22Ishibe+S%22">Ishibe S</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.<br /><searchLink fieldCode="AU" term="%22Heeger+PS%22">Heeger PS</searchLink>; Cedars-Sinai Medical Center, Los Angeles, United States of America.<br /><searchLink fieldCode="AU" term="%22Menon+MC%22">Menon MC</searchLink>; Section of Nephrology, Yale University School of Medicine, New Haven, United States of America.
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