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Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.

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Title: Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.
Authors: Cook AK; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Lin B; Department of Pathology, Division of Neuropathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Song Y; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Greathouse KM; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Kaplelach AK; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Love ML; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Davis SE; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Stoll AC; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Hall JA; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Hakim AR; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Hel JF; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Vollmer GA; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Howard AC; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Cooper NH; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Manuel PN; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Eberhardt JM; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Miller CR; Department of Pathology, Division of Neuropathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Harms AS; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Herskowitz JH; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Rizzardi LF; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Arrant AE; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: andrewarrant@uabmc.edu.
Source: Neurobiology of disease [Neurobiol Dis] 2026 Sep; Vol. 227, pp. 107475. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
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  Data: Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.
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  Data: <searchLink fieldCode="AU" term="%22Cook+AK%22">Cook AK</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Lin+B%22">Lin B</searchLink>; Department of Pathology, Division of Neuropathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Greathouse+KM%22">Greathouse KM</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kaplelach+AK%22">Kaplelach AK</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Love+ML%22">Love ML</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Davis+SE%22">Davis SE</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Stoll+AC%22">Stoll AC</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Hall+JA%22">Hall JA</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Hakim+AR%22">Hakim AR</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Hel+JF%22">Hel JF</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Vollmer+GA%22">Vollmer GA</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Howard+AC%22">Howard AC</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Cooper+NH%22">Cooper NH</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Manuel+PN%22">Manuel PN</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Eberhardt+JM%22">Eberhardt JM</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Miller+CR%22">Miller CR</searchLink>; Department of Pathology, Division of Neuropathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Harms+AS%22">Harms AS</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Herskowitz+JH%22">Herskowitz JH</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Rizzardi+LF%22">Rizzardi LF</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Arrant+AE%22">Arrant AE</searchLink>; Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: andrewarrant@uabmc.edu.
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  Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2026 Sep; Vol. 227, pp. 107475. <i>Date of Electronic Publication: </i>2026 Jun 08.
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