Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.

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Title: Prefrontal parvalbumin neurons mediate working memory in a task demand-dependent manner.
Authors: Dexter TD; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu., Machado MMF; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Hamidullah S; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Palmer D; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Hashad AM; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Doyle M; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Attard M; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Allman BL; Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Inoue W; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Saksida LM; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Bussey TJ; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Source: Nature communications [Nat Commun] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Dexter+TD%22">Dexter TD</searchLink>; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada. tydexter@health.ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Machado+MMF%22">Machado MMF</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hamidullah+S%22">Hamidullah S</searchLink>; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Palmer+D%22">Palmer D</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hashad+AM%22">Hashad AM</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.<br /><searchLink fieldCode="AU" term="%22Doyle+M%22">Doyle M</searchLink>; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Attard+M%22">Attard M</searchLink>; Neuroscience Program, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Allman+BL%22">Allman BL</searchLink>; Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Inoue+W%22">Inoue W</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Saksida+LM%22">Saksida LM</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bussey+TJ%22">Bussey TJ</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.; Department of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
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