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Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging.

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Title: Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging.
Authors: Masika H; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Ruppo S; Info-CORE Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem, Jerusalem, Israel.; Azrieli Omics Center, Center for Computational Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Clark SJ; Cambridge Institute of Science, Altos Labs, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK., Bonder MJ; Division of Computational Genomics and Systems Genetics, German Cancer Research Center, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., von Meyenn F; Laboratory of Nutrition and Metabolic Epigenetics, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.; Department of Medical and Molecular Genetics, King's College London, London, UK., Hecht M; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Orlanski S; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Katsman E; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Vardi-Yaakov O; Info-CORE Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem, Jerusalem, Israel.; Azrieli Omics Center, Center for Computational Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel., Zlotogorski A; Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel., Fachler-Sharp T; Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel., Elgavish S; Info-CORE Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem, Jerusalem, Israel.; Azrieli Omics Center, Center for Computational Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Dor Y; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.; Center for Computational Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Reik W; Cambridge Institute of Science, Altos Labs, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK., Kaplan T; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; Center for Computational Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; Barts Cancer Institute, Queen Mary University of London, London, UK. tommy.kaplan@mail.huji.ac.il.; Centre for Epigenetics, Queen Mary University of London, London, UK. tommy.kaplan@mail.huji.ac.il., Cedar H; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. cedar@mail.huji.ac.il.; Center for Computational Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. cedar@mail.huji.ac.il.
Source: Nature communications [Nat Commun] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Masika+H%22">Masika H</searchLink>; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Ruppo+S%22">Ruppo S</searchLink>; Info-CORE Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem, Jerusalem, Israel.; Azrieli Omics Center, Center for Computational Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Clark+SJ%22">Clark SJ</searchLink>; Cambridge Institute of Science, Altos Labs, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bonder+MJ%22">Bonder MJ</searchLink>; Division of Computational Genomics and Systems Genetics, German Cancer Research Center, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; 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Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Vardi-Yaakov+O%22">Vardi-Yaakov O</searchLink>; Info-CORE Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem, Jerusalem, Israel.; Azrieli Omics Center, Center for Computational Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Zlotogorski+A%22">Zlotogorski A</searchLink>; Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Fachler-Sharp+T%22">Fachler-Sharp T</searchLink>; Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Elgavish+S%22">Elgavish S</searchLink>; Info-CORE Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem, Jerusalem, Israel.; Azrieli Omics Center, Center for Computational Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Dor+Y%22">Dor Y</searchLink>; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.; Center for Computational Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Reik+W%22">Reik W</searchLink>; Cambridge Institute of Science, Altos Labs, Cambridge, UK.; Epigenetics Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kaplan+T%22">Kaplan T</searchLink>; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; Center for Computational Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; Barts Cancer Institute, Queen Mary University of London, London, UK. tommy.kaplan@mail.huji.ac.il.; Centre for Epigenetics, Queen Mary University of London, London, UK. tommy.kaplan@mail.huji.ac.il.<br /><searchLink fieldCode="AU" term="%22Cedar+H%22">Cedar H</searchLink>; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. cedar@mail.huji.ac.il.; Center for Computational Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. cedar@mail.huji.ac.il.
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