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Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.

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Title: Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.
Authors: Cheng SF; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Lin YT; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC., Wang TH; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Department of Hepato-Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC., Leu YL; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Hsia KC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC., Lee WC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC., Feng CH; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Kuo CH; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC., Yang SH; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Wang MC; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Gynecology Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Liu CY; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Hu PC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC., Hsieh YC; Office of the Texas State Chemist, AgriLife Research, Texas A&M University System, College Station, TX, USA., Yang CW; Department of Nephrology and Kidney Research Center, School of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Wang SH; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC., Yu JS; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw., Chen CY; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw., Chen CC; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+SF%22">Cheng SF</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+YT%22">Lin YT</searchLink>; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Wang+TH%22">Wang TH</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Department of Hepato-Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Leu+YL%22">Leu YL</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsia+KC%22">Hsia KC</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lee+WC%22">Lee WC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Feng+CH%22">Feng CH</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Kuo+CH%22">Kuo CH</searchLink>; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Yang+SH%22">Yang SH</searchLink>; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Wang+MC%22">Wang MC</searchLink>; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Division of Chinese Gynecology Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Liu+CY%22">Liu CY</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hu+PC%22">Hu PC</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsieh+YC%22">Hsieh YC</searchLink>; Office of the Texas State Chemist, AgriLife Research, Texas A&M University System, College Station, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yang+CW%22">Yang CW</searchLink>; Department of Nephrology and Kidney Research Center, School of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Wang+SH%22">Wang SH</searchLink>; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Yu+JS%22">Yu JS</searchLink>; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. yusong@mail.cgu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw.; Graduate Institute of Health Industry Technology and Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan, Taiwan, ROC. cychen@mail.cgust.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.; Biobank, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. chinchuan@mail.cgu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jun 10. <i>Date of Electronic Publication: </i>2026 Jun 10.
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