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Hybrid solid-liquid optics enable scalable, high-resolution light-sheet microscopy across diverse immersion media.

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Title: Hybrid solid-liquid optics enable scalable, high-resolution light-sheet microscopy across diverse immersion media.
Authors: Gong C; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Affatato P; Department of Biological Sciences, Columbia University, New York, NY, USA., Fay M; MBF Bioscience, Williston, VT, USA., Guttikonda SR; Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY, USA., O'Connor NJ; MBF Bioscience, Williston, VT, USA.; Arnas Technologies, Essex Junction, VT, USA., Noble E; MBF Bioscience, Williston, VT, USA., Heal M; MBF Bioscience, Williston, VT, USA., Haydock B; MBF Bioscience, Williston, VT, USA., Mapa R; Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA., De La Cruz ED; Department of Biological Sciences, Columbia University, New York, NY, USA., Gattoni G; Department of Biological Sciences, Columbia University, New York, NY, USA., Kowalko JE; Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA., Tosches MA; Department of Biological Sciences, Columbia University, New York, NY, USA., Gerfen CR; Section on Neuroanatomy, National Institute of Mental Health, Bethesda, MD, USA., Hen R; Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY, USA.; Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY, USA., Makinson CD; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA., Hibshoosh H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Glaser JR; MBF Bioscience, Williston, VT, USA., Tomer R; Department of Biological Sciences, Columbia University, New York, NY, USA. raju.tomer@columbia.edu.; Department of Biomedical Engineering, Columbia University, New York, NY, USA. raju.tomer@columbia.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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