Hybrid solid-liquid optics enable scalable, high-resolution light-sheet microscopy across diverse immersion media. - Gong C; Affatato P; Fay M; Guttikonda SR; O'Connor NJ; Noble E; Heal M; Haydock B; Mapa R; De La Cruz ED; Gattoni G; Kowalko JE; et al. (Nature biotechnology, 2026)