Lactate-mediated cholesterol uptake promotes liver cancer progression via the SCARB1-autophagy axis.
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| Title: | Lactate-mediated cholesterol uptake promotes liver cancer progression via the SCARB1-autophagy axis. |
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| Authors: | Chen J; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China.; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China., Zhao M; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Ji G; Oncology Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Liu K; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Shen S; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China.; Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Li ST; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.; Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Cai J; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Sun L; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China., Li J; Oncology Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. JL@gzlab.ac.cn., Gao P; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China. pgao2@ustc.edu.cn.; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China. pgao2@ustc.edu.cn.; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. pgao2@ustc.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. pgao2@ustc.edu.cn., Zhang T; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China. tzhang11@mail.ustc.edu.cn. |
| Source: | EMBO reports [EMBO Rep] 2026 Jul; Vol. 27 (14), pp. 4141-4165. Date of Electronic Publication: 2026 Jun 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42265306 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lactate-mediated cholesterol uptake promotes liver cancer progression via the SCARB1-autophagy axis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China.; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+M%22">Zhao M</searchLink>; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ji+G%22">Ji G</searchLink>; Oncology Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China.; Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Li+ST%22">Li ST</searchLink>; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.; Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Cai+J%22">Cai J</searchLink>; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Oncology Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. JL@gzlab.ac.cn.<br /><searchLink fieldCode="AU" term="%22Gao+P%22">Gao P</searchLink>; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China. pgao2@ustc.edu.cn.; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China. pgao2@ustc.edu.cn.; Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. pgao2@ustc.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. pgao2@ustc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China. tzhang11@mail.ustc.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 Jul; Vol. 27 (14), pp. 4141-4165. <i>Date of Electronic Publication: </i>2026 Jun 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100963049 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-3178 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221469221X%22">1469221X </searchLink><i>NLM ISO Abbreviation: </i>EMBO Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42265306 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s44319-026-00829-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 4141 Titles: – TitleFull: Lactate-mediated cholesterol uptake promotes liver cancer progression via the SCARB1-autophagy axis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen J – PersonEntity: Name: NameFull: Zhao M – PersonEntity: Name: NameFull: Ji G – PersonEntity: Name: NameFull: Liu K – PersonEntity: Name: NameFull: Shen S – PersonEntity: Name: NameFull: Li ST – PersonEntity: Name: NameFull: Cai J – PersonEntity: Name: NameFull: Sun L – PersonEntity: Name: NameFull: Li J – PersonEntity: Name: NameFull: Gao P – PersonEntity: Name: NameFull: Zhang T IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1469-3178 Numbering: – Type: volume Value: 27 – Type: issue Value: 14 Titles: – TitleFull: EMBO reports Type: main |
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