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Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.

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Title: Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.
Authors: Skelton M; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Mitchell BL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Assary E; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Li D; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Morneau-Vaillancourt G; Research Centre of the Montreal University Institute of Mental Health, University of Montreal, Montreal, Quebec, Canada., Murphy AE; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Ter Kuile AR; Department of Clinical, Educational, and Health Psychology, University College London, London, UK., Wang R; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK., Adams MJ; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Byrne EM; The University of Queensland, Child Health Research Centre, Brisbane, Queensland, Australia., Corfield EC; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Psychiatric Genetic Epidemiology Group, Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Grimes PZ; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Hannigan LJ; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Psychiatric Genetic Epidemiology Group, Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hu J; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Kõiv K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kwong ASF; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Papiol S; Department Clinical Translation, Max Planck Institute of Psychiatry, Munich, Germany.; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Pettersen JH; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Pistis G; Department of Psychiatry, Lausanne University Hospital (CHUV) and University of Lausanne, Prilly, Switzerland., Castelao E; Department of Psychiatry, Lausanne University Hospital (CHUV) and University of Lausanne, Prilly, Switzerland., Strom NI; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute of Psychiatric Phenomics and Genomics, LMU Munich, University Hospital, Munich, Germany.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Solna, Sweden.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., van der Most PJ; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Andreassen OA; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Erhardt-Lehmann A; Department Clinical Translation, Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany., Havdahl A; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Psychiatric Genetic Epidemiology Group, Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway., Skene N; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Verhulst B; Department of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, USA., Weber H; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany., Armour C; Stress, Trauma and Related Conditions Research Centre (STARC), School of Psychology, Queen's University Belfast, Belfast, UK., Ask H; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Copeland WE; Department of Psychiatry, University of Vermont, Burlington, VT, USA., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University, Bielefeld, Germany.; German Center for Mental Health (DZPG), Site Jena Magdeburg Halle, Jena, Germany.; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Site Jena Magdeburg Halle, Jena, Germany., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.; Institute of Clinical Epidemiology and Biometrics, University of Würzburg, Würzburg, Germany., Domschke K; Department of Psychiatry and Psychotherapy, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin-Potsdam, Berlin, Germany., Hickie IB; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia., Lehto K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lonsdorf TB; Experimental Medicine, Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany.; Psychology, Biological Psychology and Cognitive Neuroscience, University of Bielefeld, Bielefeld, Germany., Lueken U; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin-Potsdam, Berlin, Germany., Lupton MK; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Medland SE; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia., McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Oldehinkel AJ; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Preisig M; Department of Psychiatry, Lausanne University Hospital (CHUV) and University of Lausanne, Prilly, Switzerland., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Medical Centre Frankfurt, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Walters JTR; National Centre for Mental Health and Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Hartman CA; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Martin NG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Hettema JM; Department of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, USA., Breen G; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK., Coleman JRI; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK., Eley TC; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. thalia.eley@kcl.ac.uk.; National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. thalia.eley@kcl.ac.uk.
Corporate Authors: Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, GLAD+ authors, Lifelines Cohort Study, NIHR BioResource, PROTECT-AD Consortium
Source: Nature human behaviour [Nat Hum Behav] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Publishing Country of Publication: England NLM ID: 101697750 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-3374 (Electronic) Linking ISSN: 23973374 NLM ISO Abbreviation: Nat Hum Behav Subsets: MEDLINE
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            NameFull: van der Most PJ
      – PersonEntity:
          Name:
            NameFull: Andreassen OA
      – PersonEntity:
          Name:
            NameFull: Erhardt-Lehmann A
      – PersonEntity:
          Name:
            NameFull: Havdahl A
      – PersonEntity:
          Name:
            NameFull: Skene N
      – PersonEntity:
          Name:
            NameFull: Verhulst B
      – PersonEntity:
          Name:
            NameFull: Weber H
      – PersonEntity:
          Name:
            NameFull: Armour C
      – PersonEntity:
          Name:
            NameFull: Ask H
      – PersonEntity:
          Name:
            NameFull: Copeland WE
      – PersonEntity:
          Name:
            NameFull: Dannlowski U
      – PersonEntity:
          Name:
            NameFull: Deckert J
      – PersonEntity:
          Name:
            NameFull: Domschke K
      – PersonEntity:
          Name:
            NameFull: Hickie IB
      – PersonEntity:
          Name:
            NameFull: Lehto K
      – PersonEntity:
          Name:
            NameFull: Lonsdorf TB
      – PersonEntity:
          Name:
            NameFull: Lueken U
      – PersonEntity:
          Name:
            NameFull: Lupton MK
      – PersonEntity:
          Name:
            NameFull: Medland SE
      – PersonEntity:
          Name:
            NameFull: McIntosh AM
      – PersonEntity:
          Name:
            NameFull: Oldehinkel AJ
      – PersonEntity:
          Name:
            NameFull: Preisig M
      – PersonEntity:
          Name:
            NameFull: Reif A
      – PersonEntity:
          Name:
            NameFull: Snieder H
      – PersonEntity:
          Name:
            NameFull: Walters JTR
      – PersonEntity:
          Name:
            NameFull: Wray NR
      – PersonEntity:
          Name:
            NameFull: Hartman CA
      – PersonEntity:
          Name:
            NameFull: Martin NG
      – PersonEntity:
          Name:
            NameFull: Hettema JM
      – PersonEntity:
          Name:
            NameFull: Breen G
      – PersonEntity:
          Name:
            NameFull: Coleman JRI
      – PersonEntity:
          Name:
            NameFull: Eley TC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 06
              Text: 2026 Jun 09
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2397-3374
          Titles:
            – TitleFull: Nature human behaviour
              Type: main
ResultId 1