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Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.

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Title: Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.
Authors: Yu TW; Department of Internal medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Chen IC; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.; Master Program in Precision Health, National Chung Hsing University, Taichung, Taiwan, ROC., Lin GC; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC., Kao CM; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Xitun Dist, Taichung City, 407, Taiwan., Chen YJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Xitun Dist, Taichung City, 407, Taiwan., Chen YM; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Graduate Institute of Clinical Medicine, National Chung-Hsing University, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Precision Medicine Research Center, College of Medicine, National Chung Hsing University, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Xitun Dist, Taichung City, 407, Taiwan. ymchen1@vghtc.gov.tw.
Source: Scientific reports [Sci Rep] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.
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  Data: <searchLink fieldCode="AU" term="%22Yu+TW%22">Yu TW</searchLink>; Department of Internal medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chen+IC%22">Chen IC</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.; Master Program in Precision Health, National Chung Hsing University, Taichung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+GC%22">Lin GC</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Kao+CM%22">Kao CM</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Xitun Dist, Taichung City, 407, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Xitun Dist, Taichung City, 407, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YM%22">Chen YM</searchLink>; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Graduate Institute of Clinical Medicine, National Chung-Hsing University, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Precision Medicine Research Center, College of Medicine, National Chung Hsing University, Taichung, Taiwan, ROC. ymchen1@vghtc.gov.tw.; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Xitun Dist, Taichung City, 407, Taiwan. ymchen1@vghtc.gov.tw.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Jun 09. <i>Date of Electronic Publication: </i>2026 Jun 09.
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        Value: 10.1038/s41598-026-54386-3
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        Text: English
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      – TitleFull: Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.
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            – D: 09
              M: 06
              Text: 2026 Jun 09
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              Y: 2026
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