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To cleave or not to cleave: a systemic evaluation of DSS versus DSSO for cross-linking mass spectrometry analysis.

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Title: To cleave or not to cleave: a systemic evaluation of DSS versus DSSO for cross-linking mass spectrometry analysis.
Authors: Cao Y; National Institute of Biological Sciences, Beijing, Beijing, China., Mao PZ; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Wu QC; National Institute of Biological Sciences, Beijing, Beijing, China., Chen ZL; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Yang JC; National Institute of Biological Sciences, Beijing, Beijing, China., Zhao Y; National Institute of Biological Sciences, Beijing, Beijing, China., Memetimin A; National Institute of Biological Sciences, Beijing, Beijing, China., Chi H; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Qi XB; National Institute of Biological Sciences, Beijing, Beijing, China. qixiangbing@nibs.ac.cn.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. qixiangbing@nibs.ac.cn., He SM; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China. smhe@ict.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. smhe@ict.ac.cn., Dong MQ; National Institute of Biological Sciences, Beijing, Beijing, China. dongmengqiu@nibs.ac.cn.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. dongmengqiu@nibs.ac.cn.
Source: Molecular systems biology [Mol Syst Biol] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: To cleave or not to cleave: a systemic evaluation of DSS versus DSSO for cross-linking mass spectrometry analysis.
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  Data: <searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Mao+PZ%22">Mao PZ</searchLink>; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+QC%22">Wu QC</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+ZL%22">Chen ZL</searchLink>; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+JC%22">Yang JC</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Memetimin+A%22">Memetimin A</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chi+H%22">Chi H</searchLink>; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Qi+XB%22">Qi XB</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China. qixiangbing@nibs.ac.cn.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. qixiangbing@nibs.ac.cn.<br /><searchLink fieldCode="AU" term="%22He+SM%22">He SM</searchLink>; Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing, China. smhe@ict.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. smhe@ict.ac.cn.<br /><searchLink fieldCode="AU" term="%22Dong+MQ%22">Dong MQ</searchLink>; National Institute of Biological Sciences, Beijing, Beijing, China. dongmengqiu@nibs.ac.cn.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. dongmengqiu@nibs.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22101235389%22">Molecular systems biology</searchLink> [Mol Syst Biol] 2026 Jun 09. <i>Date of Electronic Publication: </i>2026 Jun 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101235389 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1744-4292 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217444292%22">17444292 </searchLink><i>NLM ISO Abbreviation: </i>Mol Syst Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s44320-026-00222-9
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        Text: English
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      – TitleFull: To cleave or not to cleave: a systemic evaluation of DSS versus DSSO for cross-linking mass spectrometry analysis.
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            – D: 09
              M: 06
              Text: 2026 Jun 09
              Type: published
              Y: 2026
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