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A method utilizing chemical carcinogens and a Western diet to reliably induce advanced hepatocellular carcinoma in male and female mice.

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Title: A method utilizing chemical carcinogens and a Western diet to reliably induce advanced hepatocellular carcinoma in male and female mice.
Authors: Mancini MC; Molecular Metabolism Lab, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Adams ER; Molecular Metabolism Lab, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Burk DH; Cell Biology and Bioimaging Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Carmouche RP; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Webb SM; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Staszkiewicz J; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Salbaum JM; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Mackintosh SG; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Heden TD; Molecular Metabolism Lab, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA. timothy.heden@pbrc.edu.
Source: Cancer & metabolism [Cancer Metab] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab
Database: MEDLINE Ultimate
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An: 42265746
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PubType: Academic Journal
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  Data: A method utilizing chemical carcinogens and a Western diet to reliably induce advanced hepatocellular carcinoma in male and female mice.
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  Data: <searchLink fieldCode="AU" term="%22Mancini+MC%22">Mancini MC</searchLink>; Molecular Metabolism Lab, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.<br /><searchLink fieldCode="AU" term="%22Adams+ER%22">Adams ER</searchLink>; Molecular Metabolism Lab, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.<br /><searchLink fieldCode="AU" term="%22Burk+DH%22">Burk DH</searchLink>; Cell Biology and Bioimaging Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Carmouche+RP%22">Carmouche RP</searchLink>; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Webb+SM%22">Webb SM</searchLink>; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Staszkiewicz+J%22">Staszkiewicz J</searchLink>; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Salbaum+JM%22">Salbaum JM</searchLink>; Genomics Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Molecular Mechanisms Core, Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Mackintosh+SG%22">Mackintosh SG</searchLink>; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Heden+TD%22">Heden TD</searchLink>; Molecular Metabolism Lab, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA. timothy.heden@pbrc.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101607582 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2049-3002 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220493002%22">20493002 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Metab
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        Value: 10.1186/s40170-026-00441-6
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      – Code: eng
        Text: English
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              M: 06
              Text: 2026 Jun 09
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