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Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II.

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Title: Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II.
Authors: Doi S; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA., Kazui S; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA., Akashi N; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA., Patel RB; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Komtebedde J; Corvia Medical, Tewksbury, Massachusetts, USA., Mylavarapu U; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Swarup V; Arizona Heart Rhythm Center, Phoenix, USA., Winkler S; Department of Internal Medicine, BG Klinikum Unfallkrankenhaus, Berlin, Germany., Backhaus SJ; Department of Cardiology, Campus Kerckhoff of the Justus-Liebig-University Giessen, Kerckhoff-Clinic, Bad Nauheim, Germany., Litwin SE; Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina, USA; Ralph H. Johnson Veterans Affairs Health System, Charleston, South Carolina, USA., Mohan RC; Scripps Clinic, La Jolla, California, USA., Kawash R; Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA., Sverdlov AL; Cardiovascular Department, John Hunter Hospital, University of Newcastle, New Lambton Heights, Australia., Chung ES; Department of Cardiovascular Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Kaye DM; Department of Cardiology, Alfred Hospital, Melbourne, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Monash-Alfred-Baker Centre for Cardiovascular Research, Melbourne, Australia; Baker Heart and Diabetes Institute, Melbourne, Australia., Hoendermis E; Department of Cardiology, Centre for Congenital Heart Disease, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Hummel SL; University of Michigan and VA Ann Arbor Health System, Ann Arbor, Michigan, USA., Cikes M; Department of Cardiovascular Diseases, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia., Hayward CS; Department of Heart and Lung Transplantation, St Vincent's Hospital, Sydney, Australia., Starling R; Department of Cardiovascular Medicine, Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA., Gupta DK; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Zirlik A; Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria., McKenzie S; The Prince Charles Hospital, School of Medicine, University of Queensland, Brisbane, Queensland, Australia., Nair A; Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany., Rieth A; German Center for Cardiovascular, Research, Partner Site RheinMain, Frankfurt AM Main, Germany., Cutlip DE; Baim Clinical Research Institute, Boston, Massachusetts, USA., Solomon SD; Brigham and Women's Hospital, Boston, Massachusetts, USA., van Veldhuisen DJ; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Leon MB; Departmen of Internal Medicine, Columbia University and Cardiovascular Research Foundation, New York City, New York, USA., Silvestry FE; Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shah SJ; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Borlaug BA; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: borlaug.barry@mayo.edu.
Source: JACC. Heart failure [JACC Heart Fail] 2026 Jun 05, pp. 103167. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101598241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1787 (Electronic) Linking ISSN: 22131779 NLM ISO Abbreviation: JACC Heart Fail Subsets: MEDLINE
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  Data: Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II.
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  Data: <searchLink fieldCode="AU" term="%22Doi+S%22">Doi S</searchLink>; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Kazui+S%22">Kazui S</searchLink>; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Akashi+N%22">Akashi N</searchLink>; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Patel+RB%22">Patel RB</searchLink>; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Komtebedde+J%22">Komtebedde J</searchLink>; Corvia Medical, Tewksbury, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mylavarapu+U%22">Mylavarapu U</searchLink>; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Swarup+V%22">Swarup V</searchLink>; Arizona Heart Rhythm Center, Phoenix, USA.<br /><searchLink fieldCode="AU" term="%22Winkler+S%22">Winkler S</searchLink>; Department of Internal Medicine, BG Klinikum Unfallkrankenhaus, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Backhaus+SJ%22">Backhaus SJ</searchLink>; Department of Cardiology, Campus Kerckhoff of the Justus-Liebig-University Giessen, Kerckhoff-Clinic, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Litwin+SE%22">Litwin SE</searchLink>; Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina, USA; Ralph H. Johnson Veterans Affairs Health System, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Mohan+RC%22">Mohan RC</searchLink>; Scripps Clinic, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Kawash+R%22">Kawash R</searchLink>; Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Sverdlov+AL%22">Sverdlov AL</searchLink>; Cardiovascular Department, John Hunter Hospital, University of Newcastle, New Lambton Heights, Australia.<br /><searchLink fieldCode="AU" term="%22Chung+ES%22">Chung ES</searchLink>; Department of Cardiovascular Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kaye+DM%22">Kaye DM</searchLink>; Department of Cardiology, Alfred Hospital, Melbourne, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Monash-Alfred-Baker Centre for Cardiovascular Research, Melbourne, Australia; Baker Heart and Diabetes Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Hoendermis+E%22">Hoendermis E</searchLink>; Department of Cardiology, Centre for Congenital Heart Disease, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hummel+SL%22">Hummel SL</searchLink>; University of Michigan and VA Ann Arbor Health System, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Cikes+M%22">Cikes M</searchLink>; Department of Cardiovascular Diseases, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Hayward+CS%22">Hayward CS</searchLink>; Department of Heart and Lung Transplantation, St Vincent's Hospital, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Starling+R%22">Starling R</searchLink>; Department of Cardiovascular Medicine, Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+DK%22">Gupta DK</searchLink>; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Zirlik+A%22">Zirlik A</searchLink>; Department of Internal Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22McKenzie+S%22">McKenzie S</searchLink>; The Prince Charles Hospital, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Nair+A%22">Nair A</searchLink>; Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Rieth+A%22">Rieth A</searchLink>; German Center for Cardiovascular, Research, Partner Site RheinMain, Frankfurt AM Main, Germany.<br /><searchLink fieldCode="AU" term="%22Cutlip+DE%22">Cutlip DE</searchLink>; Baim Clinical Research Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Solomon+SD%22">Solomon SD</searchLink>; Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22van+Veldhuisen+DJ%22">van Veldhuisen DJ</searchLink>; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Leon+MB%22">Leon MB</searchLink>; Departmen of Internal Medicine, Columbia University and Cardiovascular Research Foundation, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Silvestry+FE%22">Silvestry FE</searchLink>; Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Shah+SJ%22">Shah SJ</searchLink>; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Borlaug+BA%22">Borlaug BA</searchLink>; Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: borlaug.barry@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%22101598241%22">JACC. Heart failure</searchLink> [JACC Heart Fail] 2026 Jun 05, pp. 103167. <i>Date of Electronic Publication: </i>2026 Jun 05.
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