Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease.
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| Title: | Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease. |
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| Authors: | Howard CJ; Octant, Inc, Emeryville, United States., Abell NS; Octant, Inc, Emeryville, United States., Warneford-Thomson RR; Octant, Inc, Emeryville, United States., Mahdavi E; Octant, Inc, Emeryville, United States., Su AL; Octant, Inc, Emeryville, United States., Resnick C; Octant, Inc, Emeryville, United States., Mohammed N; Octant, Inc, Emeryville, United States., Thompson EM; Octant, Inc, Emeryville, United States., Holzinger ER; Bristol-Myers Squibb, New York, United States., Catalano K; Bristol-Myers Squibb, New York, United States., Hukku A; Bristol-Myers Squibb, New York, United States., Mintier GA; Bristol-Myers Squibb, New York, United States., MacKenzie M; Octant, Inc, Emeryville, United States., Jiang BL; Octant, Inc, Emeryville, United States., Barbosa Rabago D; Octant, Inc, Emeryville, United States., Chan A; Bristol-Myers Squibb, New York, United States., Ntimi C; Bristol-Myers Squibb, New York, United States., Weiler KN; Bristol-Myers Squibb, New York, United States., Wilson SC; Bristol-Myers Squibb, New York, United States., Maranville JC; Bristol-Myers Squibb, New York, United States., Sheth PR; Bristol-Myers Squibb, New York, United States., Plenge RM; Bristol-Myers Squibb, New York, United States., Kosuri S; Octant, Inc, Emeryville, United States., Dickel DE; Octant, Inc, Emeryville, United States. |
| Source: | ELife [Elife] 2026 Jun 10; Vol. 15. Date of Electronic Publication: 2026 Jun 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42268925 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Howard+CJ%22">Howard CJ</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Abell+NS%22">Abell NS</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Warneford-Thomson+RR%22">Warneford-Thomson RR</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Mahdavi+E%22">Mahdavi E</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Su+AL%22">Su AL</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Resnick+C%22">Resnick C</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Mohammed+N%22">Mohammed N</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Thompson+EM%22">Thompson EM</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Holzinger+ER%22">Holzinger ER</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Catalano+K%22">Catalano K</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Hukku+A%22">Hukku A</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Mintier+GA%22">Mintier GA</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22MacKenzie+M%22">MacKenzie M</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+BL%22">Jiang BL</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Barbosa+Rabago+D%22">Barbosa Rabago D</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Chan+A%22">Chan A</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Ntimi+C%22">Ntimi C</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Weiler+KN%22">Weiler KN</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+SC%22">Wilson SC</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Maranville+JC%22">Maranville JC</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Sheth+PR%22">Sheth PR</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Plenge+RM%22">Plenge RM</searchLink>; Bristol-Myers Squibb, New York, United States.<br /><searchLink fieldCode="AU" term="%22Kosuri+S%22">Kosuri S</searchLink>; Octant, Inc, Emeryville, United States.<br /><searchLink fieldCode="AU" term="%22Dickel+DE%22">Dickel DE</searchLink>; Octant, Inc, Emeryville, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101579614%22">ELife</searchLink> [Elife] 2026 Jun 10; Vol. 15. <i>Date of Electronic Publication: </i>2026 Jun 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22eLife+Sciences+Publications%2C+Ltd%22">eLife Sciences Publications, Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101579614 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2050-084X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222050084X%22">2050084X </searchLink><i>NLM ISO Abbreviation: </i>Elife <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42268925 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7554/eLife.110149 Languages: – Code: eng Text: English Titles: – TitleFull: Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Howard CJ – PersonEntity: Name: NameFull: Abell NS – PersonEntity: Name: NameFull: Warneford-Thomson RR – PersonEntity: Name: NameFull: Mahdavi E – PersonEntity: Name: NameFull: Su AL – PersonEntity: Name: NameFull: Resnick C – PersonEntity: Name: NameFull: Mohammed N – PersonEntity: Name: NameFull: Thompson EM – PersonEntity: Name: NameFull: Holzinger ER – PersonEntity: Name: NameFull: Catalano K – PersonEntity: Name: NameFull: Hukku A – PersonEntity: Name: NameFull: Mintier GA – PersonEntity: Name: NameFull: MacKenzie M – PersonEntity: Name: NameFull: Jiang BL – PersonEntity: Name: NameFull: Barbosa Rabago D – PersonEntity: Name: NameFull: Chan A – PersonEntity: Name: NameFull: Ntimi C – PersonEntity: Name: NameFull: Weiler KN – PersonEntity: Name: NameFull: Wilson SC – PersonEntity: Name: NameFull: Maranville JC – PersonEntity: Name: NameFull: Sheth PR – PersonEntity: Name: NameFull: Plenge RM – PersonEntity: Name: NameFull: Kosuri S – PersonEntity: Name: NameFull: Dickel DE IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 06 Text: 2026 Jun 10 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2050-084X Numbering: – Type: volume Value: 15 Titles: – TitleFull: ELife Type: main |
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