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The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria.

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Title: The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria.
Authors: Barber BE; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.; Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane 4006, Australia.; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Denhardt-Eriksson R; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland., Guirou EA; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland., Flynn J; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland., Sahai N; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Leelasena I; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Mathison S; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Moller C; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Lim I; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Evangelista C; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia., Webster R; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia., Potter AJ; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia., Llewellyn S; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.; Biostatistics and Data Science Division, George Institute for Global Health School of Population Health, University of New South Wales, Sydney 2031, Australia., Amante FH; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia., Gower J; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia., Peters J; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia., Khoury DS; Kirby Institute, University of New South Wales, Sydney 2052, Australia., Thathy V; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA., Narwal SK; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA., Yeo T; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA., Fidock DA; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA., Marx MW; ICON Clinical Research, 63225 Langen, Germany., Gamo FJ; Global Health Medicines R&D, GSK, 28760 Tres Cantos, Spain., Sharma R; GSK, Stevenage SG1 2FX, UK., Gibson RA; GSK, Stevenage SG1 2FX, UK., Sanz L; Global Health Medicines R&D, GSK, 28760 Tres Cantos, Spain., Cahn A; GSK, Stevenage SG1 2FX, UK., Bestgen B; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland., Chalon S; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 10; Vol. 18 (853), pp. eaec1863. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria.
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  Data: <searchLink fieldCode="AU" term="%22Barber+BE%22">Barber BE</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.; Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane 4006, Australia.; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Denhardt-Eriksson+R%22">Denhardt-Eriksson R</searchLink>; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guirou+EA%22">Guirou EA</searchLink>; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22Flynn+J%22">Flynn J</searchLink>; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sahai+N%22">Sahai N</searchLink>; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Leelasena+I%22">Leelasena I</searchLink>; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Mathison+S%22">Mathison S</searchLink>; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Moller+C%22">Moller C</searchLink>; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+I%22">Lim I</searchLink>; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Evangelista+C%22">Evangelista C</searchLink>; University of the Sunshine Coast Clinical Trials, Brisbane 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Webster+R%22">Webster R</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Potter+AJ%22">Potter AJ</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Llewellyn+S%22">Llewellyn S</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.; Biostatistics and Data Science Division, George Institute for Global Health School of Population Health, University of New South Wales, Sydney 2031, Australia.<br /><searchLink fieldCode="AU" term="%22Amante+FH%22">Amante FH</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Gower+J%22">Gower J</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Peters+J%22">Peters J</searchLink>; Department of Infection and Inflammation, QIMR Berghofer, Brisbane 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Khoury+DS%22">Khoury DS</searchLink>; Kirby Institute, University of New South Wales, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Thathy+V%22">Thathy V</searchLink>; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA.<br /><searchLink fieldCode="AU" term="%22Narwal+SK%22">Narwal SK</searchLink>; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yeo+T%22">Yeo T</searchLink>; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Department of Microbiology and Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marx+MW%22">Marx MW</searchLink>; ICON Clinical Research, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Gamo+FJ%22">Gamo FJ</searchLink>; Global Health Medicines R&D, GSK, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Sharma+R%22">Sharma R</searchLink>; GSK, Stevenage SG1 2FX, UK.<br /><searchLink fieldCode="AU" term="%22Gibson+RA%22">Gibson RA</searchLink>; GSK, Stevenage SG1 2FX, UK.<br /><searchLink fieldCode="AU" term="%22Sanz+L%22">Sanz L</searchLink>; Global Health Medicines R&D, GSK, 28760 Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Cahn+A%22">Cahn A</searchLink>; GSK, Stevenage SG1 2FX, UK.<br /><searchLink fieldCode="AU" term="%22Bestgen+B%22">Bestgen B</searchLink>; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chalon+S%22">Chalon S</searchLink>; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Jun 10; Vol. 18 (853), pp. eaec1863. <i>Date of Electronic Publication: </i>2026 Jun 10.
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