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IL-27-mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection.

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Title: IL-27-mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection.
Authors: Jeon K; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Ro HJ; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Kim J; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Lee Y; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Park U; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea., Kim Y; Department of Microbiology, Soon Chun Hyang University College of Medicine, Cheonan, Chungcheongnam-do 33151, Republic of Korea., Kim YJ; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea., Ha NY; Translational Immunology Institute, Chungnam National University, Daejeon 35015, Republic of Korea., Jeong DE; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea., Choi Y; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea., Park DJ; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea., Yun CH; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea., Kang JG; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea., Chang YH; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Jeon YK; Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea., Choi YK; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea., Jung JU; Department of Infection Biology, Global Center for Pathogen and Human Health Research, Cleveland Clinic, Cleveland, OH 44195, USA., Kim DM; Department of Internal Medicine, Chosun University College of Medicine, Gwangju 61452, Republic of Korea., Kim YS; Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea., Cho NH; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 13620, Republic of Korea.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 10; Vol. 18 (853), pp. eadu7243. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: IL-27-mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection.
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  Data: <searchLink fieldCode="AU" term="%22Jeon+K%22">Jeon K</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ro+HJ%22">Ro HJ</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+U%22">Park U</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; Department of Microbiology, Soon Chun Hyang University College of Medicine, Cheonan, Chungcheongnam-do 33151, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ha+NY%22">Ha NY</searchLink>; Translational Immunology Institute, Chungnam National University, Daejeon 35015, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+DE%22">Jeong DE</searchLink>; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+Y%22">Choi Y</searchLink>; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+DJ%22">Park DJ</searchLink>; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yun+CH%22">Yun CH</searchLink>; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+JG%22">Kang JG</searchLink>; Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chang+YH%22">Chang YH</searchLink>; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+YK%22">Jeon YK</searchLink>; Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+YK%22">Choi YK</searchLink>; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+JU%22">Jung JU</searchLink>; Department of Infection Biology, Global Center for Pathogen and Human Health Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Kim+DM%22">Kim DM</searchLink>; Department of Internal Medicine, Chosun University College of Medicine, Gwangju 61452, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YS%22">Kim YS</searchLink>; Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+NH%22">Cho NH</searchLink>; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03083, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.; Institute of Endemic Disease, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.; Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 13620, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Jun 10; Vol. 18 (853), pp. eadu7243. <i>Date of Electronic Publication: </i>2026 Jun 10.
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        Value: 10.1126/scitranslmed.adu7243
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              Text: 2026 Jun 10
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