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The role of interferon-gamma release assays in tuberculosis vaccine trials: strengths, limitations, and implications beyond trial design.

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Title: The role of interferon-gamma release assays in tuberculosis vaccine trials: strengths, limitations, and implications beyond trial design.
Authors: Dagnew AF; Gates Medical Research Institute, Cambridge, MA, USA. Electronic address: alemnew.dagnew@gatesmri.org., Schmidt AC; Gates Medical Research Institute, Cambridge, MA, USA., Cinar A; Gates Medical Research Institute, Cambridge, MA, USA., Garcia-Basteiro AL; Centro De Investigação Em Saúde De Manhiça, Manhiça, Mozambique; ISGlobal, Hospital Clínic - Universitat De Barcelona, Barcelona, Spain; Centro De Investigación Biomédica En Red De Enfermedades Infecciosas, Barcelona, Spain., Noble R; Gates Medical Research Institute, Cambridge, MA, USA., Pelzer PT; IAVI, Amsterdam, the Netherlands., Churchyard GJ; Aurum Institute, Parktown, South Africa; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; Department of Medicine, Vanderbilt University, Nashville, TN, USA., Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Cape Town, South Africa., White RG; TB Modelling Group, TB Centre and Centre for Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, London, UK., Cobelens F; Amsterdam UMC, Location University of Amsterdam, Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands; Amsterdam Public Health, Amsterdam, the Netherlands; Amsterdam Infection & Immunity, Amsterdam, the Netherlands.
Source: Vaccine [Vaccine] 2026 Jun 10; Vol. 88, pp. 128822. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The role of interferon-gamma release assays in tuberculosis vaccine trials: strengths, limitations, and implications beyond trial design.
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  Data: <searchLink fieldCode="AU" term="%22Dagnew+AF%22">Dagnew AF</searchLink>; Gates Medical Research Institute, Cambridge, MA, USA. Electronic address: alemnew.dagnew@gatesmri.org.<br /><searchLink fieldCode="AU" term="%22Schmidt+AC%22">Schmidt AC</searchLink>; Gates Medical Research Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cinar+A%22">Cinar A</searchLink>; Gates Medical Research Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Basteiro+AL%22">Garcia-Basteiro AL</searchLink>; Centro De Investigação Em Saúde De Manhiça, Manhiça, Mozambique; ISGlobal, Hospital Clínic - Universitat De Barcelona, Barcelona, Spain; Centro De Investigación Biomédica En Red De Enfermedades Infecciosas, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Noble+R%22">Noble R</searchLink>; Gates Medical Research Institute, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pelzer+PT%22">Pelzer PT</searchLink>; IAVI, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Churchyard+GJ%22">Churchyard GJ</searchLink>; Aurum Institute, Parktown, South Africa; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; Department of Medicine, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hatherill+M%22">Hatherill M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22White+RG%22">White RG</searchLink>; TB Modelling Group, TB Centre and Centre for Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Cobelens+F%22">Cobelens F</searchLink>; Amsterdam UMC, Location University of Amsterdam, Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands; Amsterdam Public Health, Amsterdam, the Netherlands; Amsterdam Infection & Immunity, Amsterdam, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%228406899%22">Vaccine</searchLink> [Vaccine] 2026 Jun 10; Vol. 88, pp. 128822. <i>Date of Electronic Publication: </i>2026 Jun 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8406899 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2518 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220264410X%22">0264410X </searchLink><i>NLM ISO Abbreviation: </i>Vaccine <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 10
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