International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.

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Title: International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.
Authors: Alexander SPH; Division of Physiology, Pharmacology and Neuroscience, Life Sciences, University of Nottingham Medical School, Nottingham, United Kingdom. Electronic address: steve.alexander@nottingham.ac.uk., Bennett KA; Nxera Pharma UK Ltd, Cambridge, United Kingdom., Brown AJ; Ikherma Consulting Ltd, Hertfordshire, United Kingdom., Glass M; School of Pharmacy and Pharmacology, University of Otago, Otago, New Zealand., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Hanson J; Laboratory of Molecular Pharmacology, GIGA Research Institute and Center of Interdisciplinary Research on Medicine, University of Liège, Liège, Belgium., Insel PA; Departments of Pharmacology and Medicine, University of California, San Diego, La Jolla, California., Kelly E; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom., Langmead CJ; Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Martemyanov KA; Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida., Neubig RR; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan and Nicholas V. Perricone, MD, Division of Dermatology, Department of Medicine, College of Human Medicine, East Lansing, Michigan., Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim Germany and Center for Molecular Medicine, Goethe-University Frankfurt, Frankfurt am Main, Germany., Rosenkilde MM; Department of Biomedical Sciences, Lab for Molecular Pharmacology, University of Copenhagen, Copenhagen, Denmark., Schulte G; Department Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm Sweden., Smith NJ; Orphan Receptor Laboratory, Department of Pharmacology, School of Biomedical Sciences, Faculty of Medicine & Health, UNSW Sydney, Sydney, Australia., Wu H; Medicine Design, Pfizer Research and Development, Pfizer Inc, Groton, Connecticut., Faccenda E; Institute for Neuroscience and Cardiovascular Research, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom., Harding SD; Institute for Neuroscience and Cardiovascular Research, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom., Davenport AP; Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Level 6, Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, United Kingdom.
Source: Pharmacological reviews [Pharmacol Rev] 2026 May 08; Vol. 78 (4), pp. 100141. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0421737 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0081 (Electronic) Linking ISSN: 00316997 NLM ISO Abbreviation: Pharmacol Rev Subsets: MEDLINE
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  Data: International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.
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  Data: <searchLink fieldCode="AU" term="%22Alexander+SPH%22">Alexander SPH</searchLink>; Division of Physiology, Pharmacology and Neuroscience, Life Sciences, University of Nottingham Medical School, Nottingham, United Kingdom. Electronic address: steve.alexander@nottingham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Bennett+KA%22">Bennett KA</searchLink>; Nxera Pharma UK Ltd, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brown+AJ%22">Brown AJ</searchLink>; Ikherma Consulting Ltd, Hertfordshire, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Glass+M%22">Glass M</searchLink>; School of Pharmacy and Pharmacology, University of Otago, Otago, New Zealand.<br /><searchLink fieldCode="AU" term="%22Gloriam+DE%22">Gloriam DE</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hanson+J%22">Hanson J</searchLink>; Laboratory of Molecular Pharmacology, GIGA Research Institute and Center of Interdisciplinary Research on Medicine, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Insel+PA%22">Insel PA</searchLink>; Departments of Pharmacology and Medicine, University of California, San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Kelly+E%22">Kelly E</searchLink>; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Langmead+CJ%22">Langmead CJ</searchLink>; Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Martemyanov+KA%22">Martemyanov KA</searchLink>; Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Neubig+RR%22">Neubig RR</searchLink>; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan and Nicholas V. Perricone, MD, Division of Dermatology, Department of Medicine, College of Human Medicine, East Lansing, Michigan.<br /><searchLink fieldCode="AU" term="%22Offermanns+S%22">Offermanns S</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim Germany and Center for Molecular Medicine, Goethe-University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenkilde+MM%22">Rosenkilde MM</searchLink>; Department of Biomedical Sciences, Lab for Molecular Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schulte+G%22">Schulte G</searchLink>; Department Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm Sweden.<br /><searchLink fieldCode="AU" term="%22Smith+NJ%22">Smith NJ</searchLink>; Orphan Receptor Laboratory, Department of Pharmacology, School of Biomedical Sciences, Faculty of Medicine & Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Medicine Design, Pfizer Research and Development, Pfizer Inc, Groton, Connecticut.<br /><searchLink fieldCode="AU" term="%22Faccenda+E%22">Faccenda E</searchLink>; Institute for Neuroscience and Cardiovascular Research, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harding+SD%22">Harding SD</searchLink>; Institute for Neuroscience and Cardiovascular Research, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davenport+AP%22">Davenport AP</searchLink>; Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Level 6, Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, United Kingdom.
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