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Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function.

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Title: Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function.
Authors: Nakhe AY; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dobson JR; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Westover D; High-Throughput Analytics, Analytical Research and Development, Merck & Co. Inc., Rahway, New Jersey., Days EL; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee., Vinson P; High-Throughput Screening Center, Southern Research, Birmingham, Alabama., Weaver CD; Department of Chemistry, Department of Pharmacology, and Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee., Denton JS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee., Peachee SJ; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Behera S; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Gibson SE; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Rodriguez Da Silva VA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Sela A; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee. Electronic address: david.a.jacobson@vanderbilt.edu.
Source: Molecular pharmacology [Mol Pharmacol] 2026 May-Jun; Vol. 108 (5-6), pp. 100130. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nakhe+AY%22">Nakhe AY</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Dobson+JR%22">Dobson JR</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Dadi+PK%22">Dadi PK</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Westover+D%22">Westover D</searchLink>; High-Throughput Analytics, Analytical Research and Development, Merck & Co. Inc., Rahway, New Jersey.<br /><searchLink fieldCode="AU" term="%22Days+EL%22">Days EL</searchLink>; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Vinson+P%22">Vinson P</searchLink>; High-Throughput Screening Center, Southern Research, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Weaver+CD%22">Weaver CD</searchLink>; Department of Chemistry, Department of Pharmacology, and Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Denton+JS%22">Denton JS</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Peachee+SJ%22">Peachee SJ</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Behera+S%22">Behera S</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Gibson+SE%22">Gibson SE</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Da+Silva+VA%22">Rodriguez Da Silva VA</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Sela+A%22">Sela A</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Dickerson+MT%22">Dickerson MT</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Jacobson+DA%22">Jacobson DA</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee. Electronic address: david.a.jacobson@vanderbilt.edu.
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  Data: <searchLink fieldCode="JN" term="%220035623%22">Molecular pharmacology</searchLink> [Mol Pharmacol] 2026 May-Jun; Vol. 108 (5-6), pp. 100130. <i>Date of Electronic Publication: </i>2026 May 15.
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