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The germline MLH1 c.2054 C>T mutation disrupts DNA mismatch repair and is detectable by digital PCR.

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Title: The germline MLH1 c.2054 C>T mutation disrupts DNA mismatch repair and is detectable by digital PCR.
Authors: Moldenhauer MR; School of Medicine, University of California Irvine, Irvine, CA, USA., Mahadevan A; School of Medicine, University of California Irvine, Irvine, CA, USA., Hom C; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Nguyen ATM; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Rangel V; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Hasson S; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA., Hsu NH; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Ubbaonu C; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA., Nathan D; School of Medicine, University of California Irvine, Irvine, CA, USA., Chandan VS; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Pathology, University of California, Irvine, Orange, CA, USA., Shen KV; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA., Damozonio EM; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Zhou GG; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA., Chichili T; Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Le A; Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA., Masri S; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Dayyani F; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Qiao F; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Valerin JB; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. Electronic address: jvalerin@hs.uci.edu., Pannunzio NR; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. Electronic address: nrpann@hs.uci.edu.
Source: Cancer letters [Cancer Lett] 2026 Sep 28; Vol. 656, pp. 218669. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
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  Data: The germline MLH1 c.2054 C>T mutation disrupts DNA mismatch repair and is detectable by digital PCR.
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  Data: <searchLink fieldCode="AU" term="%22Moldenhauer+MR%22">Moldenhauer MR</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mahadevan+A%22">Mahadevan A</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hom+C%22">Hom C</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+ATM%22">Nguyen ATM</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rangel+V%22">Rangel V</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hasson+S%22">Hasson S</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+NH%22">Hsu NH</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ubbaonu+C%22">Ubbaonu C</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nathan+D%22">Nathan D</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chandan+VS%22">Chandan VS</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Pathology, University of California, Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shen+KV%22">Shen KV</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Damozonio+EM%22">Damozonio EM</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+GG%22">Zhou GG</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chichili+T%22">Chichili T</searchLink>; Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Le+A%22">Le A</searchLink>; Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Masri+S%22">Masri S</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dayyani+F%22">Dayyani F</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Qiao+F%22">Qiao F</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Valerin+JB%22">Valerin JB</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. Electronic address: jvalerin@hs.uci.edu.<br /><searchLink fieldCode="AU" term="%22Pannunzio+NR%22">Pannunzio NR</searchLink>; School of Medicine, University of California Irvine, Irvine, CA, USA; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA. Electronic address: nrpann@hs.uci.edu.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 Sep 28; Vol. 656, pp. 218669. <i>Date of Electronic Publication: </i>2026 Jun 10.
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