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Targeting pancreatic cancer progression: The formononetin and salvianolic acid B combination suppresses JAK/STAT signaling via MBOAT2 downregulation.

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Title: Targeting pancreatic cancer progression: The formononetin and salvianolic acid B combination suppresses JAK/STAT signaling via MBOAT2 downregulation.
Authors: Xu Y; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China., Xu CS; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310009, Zhejiang Province, China; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China., Jin HB; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China., Gu WG; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China., Shen HZ; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China., Lu L; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China., Chen Y; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China., Xu DC; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China., Zhang XF; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China., Yang JF; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China., Wang Y; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China. Electronic address: wangyu@zcmu.edu.cn.
Source: Journal of integrative medicine [J Integr Med] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101603118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-4964 (Print) NLM ISO Abbreviation: J Integr Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Targeting pancreatic cancer progression: The formononetin and salvianolic acid B combination suppresses JAK/STAT signaling via MBOAT2 downregulation.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Xu+CS%22">Xu CS</searchLink>; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310009, Zhejiang Province, China; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Jin+HB%22">Jin HB</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Gu+WG%22">Gu WG</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Shen+HZ%22">Shen HZ</searchLink>; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Xu+DC%22">Xu DC</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XF%22">Zhang XF</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Yang+JF%22">Yang JF</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China; Hangzhou Institute of Digestive Diseases, Hangzhou 310006, Zhejiang Province, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China. Electronic address: wangyu@zcmu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101603118 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2095-4964 (Print) <i>NLM ISO Abbreviation: </i>J Integr Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42270536
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.joim.2026.05.003
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      – Code: eng
        Text: English
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      – TitleFull: Targeting pancreatic cancer progression: The formononetin and salvianolic acid B combination suppresses JAK/STAT signaling via MBOAT2 downregulation.
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            – D: 21
              M: 05
              Text: 2026 May 21
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