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O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling.

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Title: O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling.
Authors: Lin A; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin NY; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan., Keller M; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany., Schütz R; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany., Wu YZ; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Burton W; Department of Pharmacology, University of Oxford, Oxford, UK., Kinanti NP; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan., Yao CY; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan., Urban N; Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, Leipzig, Germany., Liu YW; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Bracher F; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany., Galione A; Department of Pharmacology, University of Oxford, Oxford, UK., Hsu HJ; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan., Kuo CY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chen CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan. chenchengchang@ntu.edu.tw.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. chenchengchang@ntu.edu.tw.
Source: Nature communications [Nat Commun] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling.
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  Data: <searchLink fieldCode="AU" term="%22Lin+A%22">Lin A</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+NY%22">Lin NY</searchLink>; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Keller+M%22">Keller M</searchLink>; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schütz+R%22">Schütz R</searchLink>; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+YZ%22">Wu YZ</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Burton+W%22">Burton W</searchLink>; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kinanti+NP%22">Kinanti NP</searchLink>; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yao+CY%22">Yao CY</searchLink>; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Urban+N%22">Urban N</searchLink>; Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+YW%22">Liu YW</searchLink>; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bracher+F%22">Bracher F</searchLink>; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Galione+A%22">Galione A</searchLink>; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hsu+HJ%22">Hsu HJ</searchLink>; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+CY%22">Kuo CY</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan. chenchengchang@ntu.edu.tw.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. chenchengchang@ntu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jun 10. <i>Date of Electronic Publication: </i>2026 Jun 10.
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              Text: 2026 Jun 10
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