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Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort.

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Title: Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort.
Authors: Ma T; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA., Liu J; Department of Psychiatry, University of California, Davis, Sacramento, 95816, CA, USA., Liang D; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA., Ebelt S; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA., Steenland K; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA., Levey AI; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, 30322, GA, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, 30322, GA, USA., Lah JJ; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, 30322, GA, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, 30322, GA, USA., Wingo AP; Department of Psychiatry, University of California, Davis, Sacramento, 95816, CA, USA.; Division of Mental Health, Northern California VA, Sacramento, 95816, CA, USA., Wingo TS; Department of Neurology, University of California, Davis, Sacramento, 95816, CA, USA.; Alzheimer's Disease Research Center, University of California, Davis, Sacramento, 95816, USA., Hüls A; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA. anke.huels@emory.edu.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA. anke.huels@emory.edu.; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, 30322, GA, USA. anke.huels@emory.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: Differential DNA methylation in blood as potential mediator of the association between ambient PM<subscript>2.5</subscript> and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort.
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  Data: <searchLink fieldCode="AU" term="%22Ma+T%22">Ma T</searchLink>; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Psychiatry, University of California, Davis, Sacramento, 95816, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+D%22">Liang D</searchLink>; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ebelt+S%22">Ebelt S</searchLink>; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.<br /><searchLink fieldCode="AU" term="%22Steenland+K%22">Steenland K</searchLink>; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA.<br /><searchLink fieldCode="AU" term="%22Levey+AI%22">Levey AI</searchLink>; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, 30322, GA, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, 30322, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lah+JJ%22">Lah JJ</searchLink>; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, 30322, GA, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, 30322, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wingo+AP%22">Wingo AP</searchLink>; Department of Psychiatry, University of California, Davis, Sacramento, 95816, CA, USA.; Division of Mental Health, Northern California VA, Sacramento, 95816, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wingo+TS%22">Wingo TS</searchLink>; Department of Neurology, University of California, Davis, Sacramento, 95816, CA, USA.; Alzheimer's Disease Research Center, University of California, Davis, Sacramento, 95816, USA.<br /><searchLink fieldCode="AU" term="%22Hüls+A%22">Hüls A</searchLink>; Ganagarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA. anke.huels@emory.edu.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, USA. anke.huels@emory.edu.; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, 30322, GA, USA. anke.huels@emory.edu.
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        Value: 10.1038/s41380-026-03662-9
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              Text: 2026 Jun 10
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