Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma.

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Title: Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Authors: Fennell É; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland. eanna.fennell@ul.ie.; Department of Pathology, School of Medicine, University College Cork, Cork, Ireland. eanna.fennell@ul.ie., Law SC; Blood Cancer Research Group, Mater Research, University of Queensland, Translational Research Institute, Brisbane, QLD, Australia., Dowell AC; School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK., Pugh MR; School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK., Enright CM; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland., Ross AM; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland., Hennessy AS; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland., Leahy CI; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland., Nikulina N; Institute for Lung Health (ILH), Justus Liebig University Giessen, Germany and Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Richter AG; Cancer Sciences, University of Birmingham, Birmingham, UK., Mundo L; Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy., Leoncini L; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Lazzi S; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Siciliano MC; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Dojcinov SD; Department of Pathology, Swansea Bay University Health Board, Swansea, UK., Quintanilla-Martinez L; Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany., Young KH; Department of Pathology, Duke University Medical Center and Duke Cancer Institute, Durham, NC, USA., Gandhi MK; Blood Cancer Research Group, Mater Research, University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.; Princess Alexandra Hospital, Brisbane, QLD, Australia., Taylor GS; School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK., Murray PG; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland. pamurray@rcsi-mub.com.; Department of Pathology, School of Medicine, Royal College of Surgeons Ireland, Muharraq, Bahrain. pamurray@rcsi-mub.com.
Source: Leukemia [Leukemia] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fennell+É%22">Fennell É</searchLink>; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland. eanna.fennell@ul.ie.; Department of Pathology, School of Medicine, University College Cork, Cork, Ireland. eanna.fennell@ul.ie.<br /><searchLink fieldCode="AU" term="%22Law+SC%22">Law SC</searchLink>; Blood Cancer Research Group, Mater Research, University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Dowell+AC%22">Dowell AC</searchLink>; School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Pugh+MR%22">Pugh MR</searchLink>; School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Enright+CM%22">Enright CM</searchLink>; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Ross+AM%22">Ross AM</searchLink>; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Hennessy+AS%22">Hennessy AS</searchLink>; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Leahy+CI%22">Leahy CI</searchLink>; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Nikulina+N%22">Nikulina N</searchLink>; Institute for Lung Health (ILH), Justus Liebig University Giessen, Germany and Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+AG%22">Richter AG</searchLink>; Cancer Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Mundo+L%22">Mundo L</searchLink>; Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Leoncini+L%22">Leoncini L</searchLink>; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzi+S%22">Lazzi S</searchLink>; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Siciliano+MC%22">Siciliano MC</searchLink>; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Dojcinov+SD%22">Dojcinov SD</searchLink>; Department of Pathology, Swansea Bay University Health Board, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Quintanilla-Martinez+L%22">Quintanilla-Martinez L</searchLink>; Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Young+KH%22">Young KH</searchLink>; Department of Pathology, Duke University Medical Center and Duke Cancer Institute, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gandhi+MK%22">Gandhi MK</searchLink>; Blood Cancer Research Group, Mater Research, University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.; Princess Alexandra Hospital, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+GS%22">Taylor GS</searchLink>; School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Murray+PG%22">Murray PG</searchLink>; School of Medicine, Bernal Institute, Limerick Digital Cancer Research Centre and Health Research Institute, University of Limerick, Limerick, Ireland. pamurray@rcsi-mub.com.; Department of Pathology, School of Medicine, Royal College of Surgeons Ireland, Muharraq, Bahrain. pamurray@rcsi-mub.com.
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