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Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains.

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Title: Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains.
Authors: Kinna A; Autolus Therapeutics Plc, London W12 7FP, UK., Datta P; Autolus Therapeutics Plc, London W12 7FP, UK., Bughda R; Autolus Therapeutics Plc, London W12 7FP, UK., Parekh F; Autolus Therapeutics Plc, London W12 7FP, UK., Robson M; Autolus Therapeutics Plc, London W12 7FP, UK., Jha R; Autolus Therapeutics Plc, London W12 7FP, UK., Wu P; Autolus Therapeutics Plc, London W12 7FP, UK., Scott I; Autolus Therapeutics Plc, London W12 7FP, UK., Hogben E; Autolus Therapeutics Plc, London W12 7FP, UK., Amin O; Autolus Therapeutics Plc, London W12 7FP, UK., Weng-Kit Cheung G; Developmental Biology and Cancer Department, The Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK., Hazelton W; Developmental Biology and Cancer Department, The Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK., Akbar Z; Autolus Therapeutics Plc, London W12 7FP, UK., Lamb K; Autolus Therapeutics Plc, London W12 7FP, UK., Macken E; Autolus Therapeutics Plc, London W12 7FP, UK., Allen C; Autolus Therapeutics Plc, London W12 7FP, UK., Panovska S; Autolus Therapeutics Plc, London W12 7FP, UK., Hogan L; Autolus Therapeutics Plc, London W12 7FP, UK., El-Kholy M; Autolus Therapeutics Plc, London W12 7FP, UK., Shrestha R; Autolus Therapeutics Plc, London W12 7FP, UK., Popplewell J; Carterra Inc, Salt Lake City, UT 84103, USA., Kokalaki E; Autolus Therapeutics Plc, London W12 7FP, UK., Sillibourne J; Autolus Therapeutics Plc, London W12 7FP, UK., Thomas S; Autolus Therapeutics Plc, London W12 7FP, UK., Onuoha S; Autolus Therapeutics Plc, London W12 7FP, UK., Ferrari M; Autolus Therapeutics Plc, London W12 7FP, UK., Pule M; Autolus Therapeutics Plc, London W12 7FP, UK; Developmental Biology and Cancer Department, The Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK. Electronic address: m.pule@autolus.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains.
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  Data: <searchLink fieldCode="AU" term="%22Kinna+A%22">Kinna A</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Datta+P%22">Datta P</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Bughda+R%22">Bughda R</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Parekh+F%22">Parekh F</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Robson+M%22">Robson M</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Jha+R%22">Jha R</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Wu+P%22">Wu P</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Scott+I%22">Scott I</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Hogben+E%22">Hogben E</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Amin+O%22">Amin O</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Weng-Kit+Cheung+G%22">Weng-Kit Cheung G</searchLink>; Developmental Biology and Cancer Department, The Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Hazelton+W%22">Hazelton W</searchLink>; Developmental Biology and Cancer Department, The Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Akbar+Z%22">Akbar Z</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Lamb+K%22">Lamb K</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Macken+E%22">Macken E</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Allen+C%22">Allen C</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Panovska+S%22">Panovska S</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Hogan+L%22">Hogan L</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22El-Kholy+M%22">El-Kholy M</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Shrestha+R%22">Shrestha R</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Popplewell+J%22">Popplewell J</searchLink>; Carterra Inc, Salt Lake City, UT 84103, USA.<br /><searchLink fieldCode="AU" term="%22Kokalaki+E%22">Kokalaki E</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Sillibourne+J%22">Sillibourne J</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+S%22">Thomas S</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Onuoha+S%22">Onuoha S</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Ferrari+M%22">Ferrari M</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK.<br /><searchLink fieldCode="AU" term="%22Pule+M%22">Pule M</searchLink>; Autolus Therapeutics Plc, London W12 7FP, UK; Developmental Biology and Cancer Department, The Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK. Electronic address: m.pule@autolus.com.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Jun 10. <i>Date of Electronic Publication: </i>2026 Jun 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ymthe.2026.06.017
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        Text: English
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      – TitleFull: Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains.
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              Text: 2026 Jun 10
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