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Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial.

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Title: Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial.
Authors: Raket LL; Eli Lilly and Company, Indianapolis, Indiana, USA., Lu M; Eli Lilly and Company, Indianapolis, Indiana, USA., Evans CD; Eli Lilly and Company, Indianapolis, Indiana, USA., Zimmer JA; Eli Lilly and Company, Indianapolis, Indiana, USA., Sparks J; Eli Lilly and Company, Indianapolis, Indiana, USA., Collins EC; Eli Lilly and Company, Indianapolis, Indiana, USA., Shcherbinin S; Eli Lilly and Company, Indianapolis, Indiana, USA., Wang H; Eli Lilly and Company, Indianapolis, Indiana, USA., Nery ESM; Eli Lilly and Company, Indianapolis, Indiana, USA., Epelbaum S; Eli Lilly and Company, Indianapolis, Indiana, USA., Dell'Agnello G; Eli Lilly and Company, Indianapolis, Indiana, USA., Brooks DA; Eli Lilly and Company, Indianapolis, Indiana, USA., Sims JR; Eli Lilly and Company, Indianapolis, Indiana, USA., Mintun MA; Eli Lilly and Company, Indianapolis, Indiana, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71577.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42273802
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Raket+LL%22">Raket LL</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Lu+M%22">Lu M</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Evans+CD%22">Evans CD</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Zimmer+JA%22">Zimmer JA</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Sparks+J%22">Sparks J</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Collins+EC%22">Collins EC</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Shcherbinin+S%22">Shcherbinin S</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Nery+ESM%22">Nery ESM</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Epelbaum+S%22">Epelbaum S</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Dell'Agnello+G%22">Dell'Agnello G</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Brooks+DA%22">Brooks DA</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Sims+JR%22">Sims JR</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Mintun+MA%22">Mintun MA</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71577.
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  Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42273802
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      – Type: doi
        Value: 10.1002/alz.71577
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      – Code: eng
        Text: English
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        StartPage: e71577
    Titles:
      – TitleFull: Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial.
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 22
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