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Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.

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Title: Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.
Authors: Granfeldt A; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Kirkegaard BL; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Denmark., Vallentin MF; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Denmark., Holmberg MJ; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Stankovic N; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark., Lind PC; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Kjærgaard AG; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Houe N; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Vested M; Department of Anaesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark., Isbye DL; Department of Anaesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark., Kristensen CM; Department of Anaesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Kjærgaard J; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Zwisler ST; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark., Lundsfryd SN; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark., Petersen LB; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark., Folke F; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev Gentofte University Hospital, Herlev, Denmark.; Emergency Medical Services, Capital Region, Copenhagen University, Copenhagen, Denmark., Hansen CM; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev Gentofte University Hospital, Herlev, Denmark.; Emergency Medical Services, Capital Region, Copenhagen University, Copenhagen, Denmark., Iversen KK; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev Gentofte University Hospital, Herlev, Denmark., Schou M; Department of Cardiology, Herlev Gentofte University Hospital, Herlev, Denmark., Wiberg S; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Riddersholm SJ; Department of Cardiology, Faculty of Medicine, Aalborg University Hospital, Aalborg, Denmark., Rasmussen BS; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Karlsson K; Department of Cardiology, Faculty of Medicine, Aalborg University Hospital, Aalborg, Denmark., Plovsing RR; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Juhl CS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Krag M; Department of Anaesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark., Sørensen CD; Department of Anaesthesiology and Intensive Care, Holbæk Hospital, Holbæk, Denmark., Kuhne-Qvist P; Esbjerg and Grindsted Hospital - University Hospital of Southern Denmark, University of Southern Denmark, Odense, Denmark., Oxlund J; Esbjerg and Grindsted Hospital - University Hospital of Southern Denmark, University of Southern Denmark, Odense, Denmark., Sølling CG; Department of Anaesthesiology and Intensive Care, Viborg Regional Hospital, Viborg, Denmark., Hansen JR; Department of Anaesthesiology and Intensive Care, Viborg Regional Hospital, Viborg, Denmark., Andersen LPK; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Jensen JMS; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Itenov TS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Lauritzen M; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Pedersen MJ; Department of Anaesthesiology and Intensive Care, Gødstrup Hospital, Herning, Denmark., Nielsen RP; Department of Anaesthesiology and Intensive Care, Gødstrup Hospital, Herning, Denmark., Fjeldsøe-Nielsen H; Department of Anaesthesiology, Zealand University Hospital, Nykøbing Falster, Denmark., Mirzada N; Department of Anaesthesiology, Zealand University Hospital, Nykøbing Falster, Denmark., Secher N; Department of Anaesthesiology and Intensive Care, Horsens Hospital, Horsens, Denmark., Espelund US; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Anaesthesiology and Intensive Care, Horsens Hospital, Horsens, Denmark., Eskol JR; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.; Department of Anaesthesia and Critical Care Medicine, Hospital Sønderjylland, Aabenraa, Denmark., Andersen K; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.; Department of Anaesthesia and Critical Care Medicine, Hospital Sønderjylland, Aabenraa, Denmark., Brøchner AC; Department of Anaesthesiology and Intensive Care, University Hospital of Southern Denmark, Kolding, Denmark., Nedergaard HK; Department of Anaesthesiology and Intensive Care, University Hospital of Southern Denmark, Kolding, Denmark., Hansen PM; Prehospital Research Unit, Prehospital South - Emergency Medical Services, Region of Southern Denmark, Odense, Denmark.; Department of Anaesthesiology and Intensive Care Medicine, Odense University Hospital Svendborg, Svendborg, Denmark., Henschel W; Department of Anaesthesiology and Intensive Care Medicine, Odense University Hospital Svendborg, Svendborg, Denmark., Walli AR; Department of Anaesthesiology, Slagelse Hospital, Slagelse, Denmark., Sandgaard M; Department of Anaesthesiology, Slagelse Hospital, Slagelse, Denmark., Asferg CL; Department of Cardiology, Zealand University Hospital, Roskilde, Denmark., Ciubotariu A; Department of Anaesthesiology and Intensive Care, North Denmark Regional Hospital, Hjørring, Denmark., Rasmussen MHR; Department of Anaesthesiology and Intensive Care, North Denmark Regional Hospital, Hjørring, Denmark., Le Breton V; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Nielsen LK; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Hansen FG; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Brændstrup N; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Thomsen IK; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Sindberg B; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Andersen LW; Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Denmark.
Corporate Authors: Bicarbonate for In-Hospital Cardiac Arrest (BIHCA) Investigators
Source: JAMA [JAMA] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.
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Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Lundsfryd+SN%22">Lundsfryd SN</searchLink>; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+LB%22">Petersen LB</searchLink>; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Folke+F%22">Folke F</searchLink>; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev Gentofte University Hospital, Herlev, Denmark.; Emergency Medical Services, Capital Region, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+CM%22">Hansen CM</searchLink>; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Herlev Gentofte University Hospital, Herlev, Denmark.; 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Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Karlsson+K%22">Karlsson K</searchLink>; Department of Cardiology, Faculty of Medicine, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Plovsing+RR%22">Plovsing RR</searchLink>; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Juhl+CS%22">Juhl CS</searchLink>; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Krag+M%22">Krag M</searchLink>; Department of Anaesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; 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Department of Anaesthesiology and Intensive Care, Gødstrup Hospital, Herning, Denmark.<br /><searchLink fieldCode="AU" term="%22Fjeldsøe-Nielsen+H%22">Fjeldsøe-Nielsen H</searchLink>; Department of Anaesthesiology, Zealand University Hospital, Nykøbing Falster, Denmark.<br /><searchLink fieldCode="AU" term="%22Mirzada+N%22">Mirzada N</searchLink>; Department of Anaesthesiology, Zealand University Hospital, Nykøbing Falster, Denmark.<br /><searchLink fieldCode="AU" term="%22Secher+N%22">Secher N</searchLink>; Department of Anaesthesiology and Intensive Care, Horsens Hospital, Horsens, Denmark.<br /><searchLink fieldCode="AU" term="%22Espelund+US%22">Espelund US</searchLink>; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Anaesthesiology and Intensive Care, Horsens Hospital, Horsens, Denmark.<br /><searchLink fieldCode="AU" term="%22Eskol+JR%22">Eskol JR</searchLink>; Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.; 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Department of Anaesthesiology and Intensive Care Medicine, Odense University Hospital Svendborg, Svendborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Walli+AR%22">Walli AR</searchLink>; Department of Anaesthesiology, Slagelse Hospital, Slagelse, Denmark.<br /><searchLink fieldCode="AU" term="%22Sandgaard+M%22">Sandgaard M</searchLink>; Department of Anaesthesiology, Slagelse Hospital, Slagelse, Denmark.<br /><searchLink fieldCode="AU" term="%22Asferg+CL%22">Asferg CL</searchLink>; Department of Cardiology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Ciubotariu+A%22">Ciubotariu A</searchLink>; Department of Anaesthesiology and Intensive Care, North Denmark Regional Hospital, Hjørring, Denmark.<br /><searchLink fieldCode="AU" term="%22Rasmussen+MHR%22">Rasmussen MHR</searchLink>; Department of Anaesthesiology and Intensive Care, North Denmark Regional Hospital, Hjørring, Denmark.<br /><searchLink fieldCode="AU" term="%22Le+Breton+V%22">Le Breton V</searchLink>; 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Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Prehospital Emergency Medical Services, Central Denmark Region, Denmark.
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      – PersonEntity:
          Name:
            NameFull: Jensen JMS
      – PersonEntity:
          Name:
            NameFull: Itenov TS
      – PersonEntity:
          Name:
            NameFull: Lauritzen M
      – PersonEntity:
          Name:
            NameFull: Pedersen MJ
      – PersonEntity:
          Name:
            NameFull: Nielsen RP
      – PersonEntity:
          Name:
            NameFull: Fjeldsøe-Nielsen H
      – PersonEntity:
          Name:
            NameFull: Mirzada N
      – PersonEntity:
          Name:
            NameFull: Secher N
      – PersonEntity:
          Name:
            NameFull: Espelund US
      – PersonEntity:
          Name:
            NameFull: Eskol JR
      – PersonEntity:
          Name:
            NameFull: Andersen K
      – PersonEntity:
          Name:
            NameFull: Brøchner AC
      – PersonEntity:
          Name:
            NameFull: Nedergaard HK
      – PersonEntity:
          Name:
            NameFull: Hansen PM
      – PersonEntity:
          Name:
            NameFull: Henschel W
      – PersonEntity:
          Name:
            NameFull: Walli AR
      – PersonEntity:
          Name:
            NameFull: Sandgaard M
      – PersonEntity:
          Name:
            NameFull: Asferg CL
      – PersonEntity:
          Name:
            NameFull: Ciubotariu A
      – PersonEntity:
          Name:
            NameFull: Rasmussen MHR
      – PersonEntity:
          Name:
            NameFull: Le Breton V
      – PersonEntity:
          Name:
            NameFull: Nielsen LK
      – PersonEntity:
          Name:
            NameFull: Hansen FG
      – PersonEntity:
          Name:
            NameFull: Brændstrup N
      – PersonEntity:
          Name:
            NameFull: Thomsen IK
      – PersonEntity:
          Name:
            NameFull: Sindberg B
      – PersonEntity:
          Name:
            NameFull: Andersen LW
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 06
              Text: 2026 Jun 11
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1538-3598
          Titles:
            – TitleFull: JAMA
              Type: main
ResultId 1