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Lactate acts as a metabolic brake on inflammation by repressing NLRP3 transcription via NF-κB inhibition.

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Title: Lactate acts as a metabolic brake on inflammation by repressing NLRP3 transcription via NF-κB inhibition.
Authors: Lin HA; Department of Internal Medicine, School of Medicine, College of Medicine, National Defense Medical University, Taipei, 114201, Taiwan.; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, 114201, Taiwan.; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, 105309, Taiwan., Lin HC; Department of Pathology, School of Medicine, College of Medicine, National Defense Medical University, Taipei, 114201, Taiwan.; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, Taipei, 114201, Taiwan., Chiou CY; Liver Research Center, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, 33305, Taiwan., Peng HH; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, 105309, Taiwan., Chen YJ; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, 251020, Taiwan.; Department of Radiation Oncology, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Department of Artificial Intelligence and Medical Application, MacKay Junior College of Medicine, Nursing and Management, Taipei, 112021, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung, 404332, Taiwan., Bao BY; Department of Pharmacy, China Medical University, Taichung, 406040, Taiwan., Tsai KJ; Department of Laboratory Medicine, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Department of Nursing, College of Nursing, MacKay Medical University, New Taipei City, 252005, Taiwan., Lin CF; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Department of Cardiology, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, 350401, Taiwan., Shih CT; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan., Hu SI; Division of Colon and Rectal Surgery, Department of Surgery, Keelung Branch of Tri-Service General Hospital, Keelung, Taiwan., Huang KY; Graduate Institute of Pathology and Parasitology, College of Medicine, National Defense Medical University, Taipei, 114201, Taiwan., Chen LC; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan. lihchyang@mmu.edu.tw.; Institute of Biomedical Science, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan. lihchyang@mmu.edu.tw.; Department of Optometry, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan. lihchyang@mmu.edu.tw.
Source: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2026 Jun 11; Vol. 75 (1). Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9508160 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-908X (Electronic) Linking ISSN: 10233830 NLM ISO Abbreviation: Inflamm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lin+HA%22">Lin HA</searchLink>; Department of Internal Medicine, School of Medicine, College of Medicine, National Defense Medical University, Taipei, 114201, Taiwan.; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, 114201, Taiwan.; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, 105309, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HC%22">Lin HC</searchLink>; Department of Pathology, School of Medicine, College of Medicine, National Defense Medical University, Taipei, 114201, Taiwan.; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, Taipei, 114201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+CY%22">Chiou CY</searchLink>; Liver Research Center, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, 33305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peng+HH%22">Peng HH</searchLink>; Department of Internal Medicine, Songshan Branch of Tri-Service General Hospital, National Defense Medical University, Taipei, 105309, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, 251020, Taiwan.; Department of Radiation Oncology, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Department of Artificial Intelligence and Medical Application, MacKay Junior College of Medicine, Nursing and Management, Taipei, 112021, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung, 404332, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bao+BY%22">Bao BY</searchLink>; Department of Pharmacy, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+KJ%22">Tsai KJ</searchLink>; Department of Laboratory Medicine, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Department of Nursing, College of Nursing, MacKay Medical University, New Taipei City, 252005, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CF%22">Lin CF</searchLink>; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Department of Cardiology, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, 350401, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+CT%22">Shih CT</searchLink>; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+SI%22">Hu SI</searchLink>; Division of Colon and Rectal Surgery, Department of Surgery, Keelung Branch of Tri-Service General Hospital, Keelung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KY%22">Huang KY</searchLink>; Graduate Institute of Pathology and Parasitology, College of Medicine, National Defense Medical University, Taipei, 114201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+LC%22">Chen LC</searchLink>; School of Medicine, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan. lihchyang@mmu.edu.tw.; Institute of Biomedical Science, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan. lihchyang@mmu.edu.tw.; Department of Optometry, College of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan. lihchyang@mmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%229508160%22">Inflammation research : official journal of the European Histamine Research Society ... [et al.]</searchLink> [Inflamm Res] 2026 Jun 11; Vol. 75 (1). <i>Date of Electronic Publication: </i>2026 Jun 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Birkhäuser%22">Birkhäuser </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9508160 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-908X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210233830%22">10233830 </searchLink><i>NLM ISO Abbreviation: </i>Inflamm Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00011-026-02290-x
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              Text: 2026 Jun 11
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              Y: 2026
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