Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures.
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| Title: | Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures. |
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| Authors: | Hua M; Department of Biochemistry and Molecular Biology and., Aghanoori MR; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., MacPherson MJ; Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada., Ren Y; Department of Cell Biology and Anatomy., Siripala SV; Department of Clinical Neuroscience, Cumming School of Medicine., Yang Y; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Or YYY; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Nguyen M; Department of Cell Biology and Anatomy., Duba-Kiss R; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute.; Hotchkiss Brain Institute, Cumming School of Medicine; and., Feng D; Department of Cell Biology and Anatomy.; Hotchkiss Brain Institute, Cumming School of Medicine; and., Williams L; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Gafuik CJ; Alberta Children's Hospital Research Institute.; Annie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Wang G; Center for Neuroscience Research, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China., Quelin C; Service de Génétique Clinique, Centre de Référence «Anomalies du Développement et Syndromes Malformatifs» de l'Inter-région Ouest, CHU Rennes Hôpital Sud, Rennes, France., Keren B; Department of Genetics, La Pitié-Salpêtrière Hospital, Assistance Publique Hospital of Paris, Paris, France.; Sorbonne University, Paris, France., Schuhmann S; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Vasileiou G; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Bourgois A; Service de Génétique, Centre Hospitalier Universitaire de Caen, Caen, Basse-Normandie, France., Vitobello A; Université Bourgogne Europe, CHU Dijon Bourgogne, Laboratoire de Génomique Médicale, Centre Neomics, FHU TRANSLAD, Centre de recherche Translationnelle en Médecine moléculaire - INSERM UMR1231, équipe GAD, Dijon, France., Philippe C; Laboratoire de Génétique, Hôpital de Mercy, CHR Metz-Thionville, Metz, France., Stark Z; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia., Leventer RJ; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia., McGillivray G; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Tran Mau-Them F; Université Bourgogne Europe, CHU Dijon Bourgogne, Laboratoire de Génomique Médicale, Centre Neomics, FHU TRANSLAD, Centre de recherche Translationnelle en Médecine moléculaire - INSERM UMR1231, équipe GAD, Dijon, France., Tessarech M; Department of Medical Genetics, Angers University Hospital, Angers, France.; Mitovasc Unit, UMR CNRS 6015 INSERM 1083, University of Angers, Angers, France., Prouteau C; Service de Génétique Médicale, CHU d'Angers, Angers, France., Lakeman P; Amsterdam UMC, Department of Human Genetics, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Reproduction & Development Research Institute, Amsterdam, Netherlands., Motazacker MM; Amsterdam UMC, Department of Human Genetics, University of Amsterdam, Amsterdam, Netherlands., Latner DR; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA., Caylor RC; Greenwood Genetic Center, Greenwood, South Carolina, USA., van Ierland Y; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands., Prijoles E; Greenwood Genetic Center, Greenwood, South Carolina, USA., Lichty A; Greenwood Genetic Center, Greenwood, South Carolina, USA., Theodorou E; Center for Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA., Sweetser DA; Center for Genomic Medicine, Divisions of Pediatric Hematology/Oncology and Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA., Steel E; Clinical Genetics, Great Ormond Street Hospital, London, United Kingdom., Cobben J; Section of Genomics and Genetics, Imperial College London, London, United Kingdom., Dasouki MJ; AdventHealth Genomics & Personalized Health at Orlando, Department of Medical Genetics & Genomics, Orlando, Florida, USA., Calame DG; Section of Pediatric Neurology and Developmental Neurosciences, Department of Pediatrics, and.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, USA., Isidor B; Nantes Université, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.; Nantes Université, CHU de Nantes, Service de Génétique médicale, Nantes, France., Cogné B; Nantes Université, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.; Nantes Université, CHU de Nantes, Service de Génétique médicale, Nantes, France., Kesler M; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute.; Hotchkiss Brain Institute, Cumming School of Medicine; and., Rackel B; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Clark I; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Kurrasch DM; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute.; Hotchkiss Brain Institute, Cumming School of Medicine; and., Teskey GC; Department of Cell Biology and Anatomy., Ellis J; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., He G; Center for Neuroscience Research, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China., Ryan SD; Department of Clinical Neuroscience, Cumming School of Medicine., Mahoney DJ; Department of Biochemistry and Molecular Biology and.; Alberta Children's Hospital Research Institute.; Annie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, and., Innes AM; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute., Epp JR; Department of Cell Biology and Anatomy.; Hotchkiss Brain Institute, Cumming School of Medicine; and., Yang G; Department of Biochemistry and Molecular Biology and.; Department of Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute.; Hotchkiss Brain Institute, Cumming School of Medicine; and.; Owerko Center, University of Calgary, Calgary, Alberta, Canada. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2026 Jun 11; Vol. 136 (14). Date of Electronic Publication: 2026 Jun 11 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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