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Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma.

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Title: Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma.
Authors: Park J; Graduate School of Stem Cell and Regeneration Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Qiu M; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Cho EJ; SG BioScience, Inc., Seoul 02637, Republic of Korea., Seo S; Department of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea., Moon JH; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Kim M; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Mun H; SG BioScience, Inc., Seoul 02637, Republic of Korea., Yun H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Park H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Lim A; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea., Kang Y; SG BioScience, Inc., Seoul 02637, Republic of Korea; Department of Medical Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea., Oh JW; SG BioScience, Inc., Seoul 02637, Republic of Korea., Youk H; SG BioScience, Inc., Seoul 02637, Republic of Korea., Kim SH; Department of Neurosurgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea., Seo Y; Department of Neurosurgery, Yeungnam University Hospital, Yeungnam University School of Medicine, Daegu 42415, Republic of Korea., Kwon SM; Department of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 41931, Republic of Korea., Sung KS; Department of Neurosurgery, Dong-A University Hospital, Dong-A University, College of Medicine, Busan 49201, Republic of Korea., Oh HJ; Department of Neurosurgery, Soonchunhyang University Hospital Cheonan, Soonchunhyang University School of Medicine, Cheonan 31151, Republic of Korea., Cho KR; Department of Neurosurgery, Konkuk University Medical Center, Seoul 05030, Republic of Korea., Yoon K; Department of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea., Kim NS; Department of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address: nskim1@cnu.ac.kr., Jang SJ; SG BioScience, Inc., Seoul 02637, Republic of Korea; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea. Electronic address: jangsejin@amc.seoul.kr., Kim KH; Department of Neurosurgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: lastbreak0@gmail.com., Yoon KJ; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Graduate School of Stem Cell and Regeneration Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea. Electronic address: kijunyoon@kaist.ac.kr.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jun 11, pp. 102850. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Graduate School of Stem Cell and Regeneration Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Qiu+M%22">Qiu M</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+EJ%22">Cho EJ</searchLink>; SG BioScience, Inc., Seoul 02637, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Seo+S%22">Seo S</searchLink>; Department of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Moon+JH%22">Moon JH</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Mun+H%22">Mun H</searchLink>; SG BioScience, Inc., Seoul 02637, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yun+H%22">Yun H</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+A%22">Lim A</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; SG BioScience, Inc., Seoul 02637, Republic of Korea; Department of Medical Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+JW%22">Oh JW</searchLink>; SG BioScience, Inc., Seoul 02637, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Youk+H%22">Youk H</searchLink>; SG BioScience, Inc., Seoul 02637, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Department of Neurosurgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Seo+Y%22">Seo Y</searchLink>; Department of Neurosurgery, Yeungnam University Hospital, Yeungnam University School of Medicine, Daegu 42415, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+SM%22">Kwon SM</searchLink>; Department of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 41931, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sung+KS%22">Sung KS</searchLink>; Department of Neurosurgery, Dong-A University Hospital, Dong-A University, College of Medicine, Busan 49201, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+HJ%22">Oh HJ</searchLink>; Department of Neurosurgery, Soonchunhyang University Hospital Cheonan, Soonchunhyang University School of Medicine, Cheonan 31151, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+KR%22">Cho KR</searchLink>; Department of Neurosurgery, Konkuk University Medical Center, Seoul 05030, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+K%22">Yoon K</searchLink>; Department of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+NS%22">Kim NS</searchLink>; Department of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address: nskim1@cnu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Jang+SJ%22">Jang SJ</searchLink>; SG BioScience, Inc., Seoul 02637, Republic of Korea; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea. Electronic address: jangsejin@amc.seoul.kr.<br /><searchLink fieldCode="AU" term="%22Kim+KH%22">Kim KH</searchLink>; Department of Neurosurgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: lastbreak0@gmail.com.<br /><searchLink fieldCode="AU" term="%22Yoon+KJ%22">Yoon KJ</searchLink>; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Graduate School of Stem Cell and Regeneration Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea. Electronic address: kijunyoon@kaist.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2026 Jun 11, pp. 102850. <i>Date of Electronic Publication: </i>2026 Jun 11.
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