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Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.

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Title: Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.
Authors: Jovanovic VM; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA. Electronic address: vukasin.jovanovic@nih.gov., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Castellano D; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Ryu S; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Tharakan R; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Mesch KT; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Chen Q; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Betül Erol FM; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Glover HJ; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Yan T; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sinha N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sen C; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Yang S; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Blivis D; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Bennett DF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Rosales-Soto G; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Inman J; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Ormanoglu P; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., LeClair CA; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Shaw ND; Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Xia M; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Schneider M; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Hernandez-Ochoa EO; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA., Erdos MR; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Simeonov A; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA., Chen S; Department of Surgery, Center for Genomic Health, Weill Cornell Medicine, New York, NY 10065, USA., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Doege CA; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Tristan CA; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA. Electronic address: carlos.tristan@nih.gov.
Source: Stem cell reports [Stem Cell Reports] 2026 Jul 14; Vol. 21 (7), pp. 102958. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
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  Data: Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.
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  Data: <searchLink fieldCode="AU" term="%22Jovanovic+VM%22">Jovanovic VM</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA. Electronic address: vukasin.jovanovic@nih.gov.<br /><searchLink fieldCode="AU" term="%22Narisu+N%22">Narisu N</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Bonnycastle+LL%22">Bonnycastle LL</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Castellano+D%22">Castellano D</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Ryu+S%22">Ryu S</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Tharakan+R%22">Tharakan R</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Mesch+KT%22">Mesch KT</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Betül+Erol+FM%22">Betül Erol FM</searchLink>; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Glover+HJ%22">Glover HJ</searchLink>; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yan+T%22">Yan T</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Sinha+N%22">Sinha N</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Sen+C%22">Sen C</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Blivis+D%22">Blivis D</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DF%22">Bennett DF</searchLink>; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rosales-Soto+G%22">Rosales-Soto G</searchLink>; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Inman+J%22">Inman J</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Ormanoglu+P%22">Ormanoglu P</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22LeClair+CA%22">LeClair CA</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+ND%22">Shaw ND</searchLink>; Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Xia+M%22">Xia M</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez-Ochoa+EO%22">Hernandez-Ochoa EO</searchLink>; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Erdos+MR%22">Erdos MR</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Simeonov+A%22">Simeonov A</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Surgery, Center for Genomic Health, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Collins+FS%22">Collins FS</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Doege+CA%22">Doege CA</searchLink>; Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tristan+CA%22">Tristan CA</searchLink>; National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation Rockville, Rockville, MD 20850, USA. Electronic address: carlos.tristan@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101611300%22">Stem cell reports</searchLink> [Stem Cell Reports] 2026 Jul 14; Vol. 21 (7), pp. 102958. <i>Date of Electronic Publication: </i>2026 Jun 11.
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