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Canagliflozin attenuates cognitive deficits in the streptozotocin-induced mouse model of sporadic Alzheimer's disease via modulating PINK1/Parkin signaling pathway and miR-34a expression.

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Title: Canagliflozin attenuates cognitive deficits in the streptozotocin-induced mouse model of sporadic Alzheimer's disease via modulating PINK1/Parkin signaling pathway and miR-34a expression.
Authors: Nadeem RI; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt. Electronic address: rania.ibrahim@hu.edu.eg., Sayed RH; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Giza, Egypt., Elbaz EM; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Abdel Rahman AAS; Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt., Saeed MM; Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
Source: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2026 Jun 11; Vol. 148, pp. 111781. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Canagliflozin attenuates cognitive deficits in the streptozotocin-induced mouse model of sporadic Alzheimer's disease via modulating PINK1/Parkin signaling pathway and miR-34a expression.
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  Data: <searchLink fieldCode="AU" term="%22Nadeem+RI%22">Nadeem RI</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt. Electronic address: rania.ibrahim@hu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Sayed+RH%22">Sayed RH</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Elbaz+EM%22">Elbaz EM</searchLink>; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdel+Rahman+AAS%22">Abdel Rahman AAS</searchLink>; Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Saeed+MM%22">Saeed MM</searchLink>; Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
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  Data: <searchLink fieldCode="JN" term="%228211617%22">Progress in neuro-psychopharmacology & biological psychiatry</searchLink> [Prog Neuropsychopharmacol Biol Psychiatry] 2026 Jun 11; Vol. 148, pp. 111781. <i>Date of Electronic Publication: </i>2026 Jun 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8211617 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-4216 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202785846%22">02785846 </searchLink><i>NLM ISO Abbreviation: </i>Prog Neuropsychopharmacol Biol Psychiatry <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.pnpbp.2026.111781
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      – TitleFull: Canagliflozin attenuates cognitive deficits in the streptozotocin-induced mouse model of sporadic Alzheimer's disease via modulating PINK1/Parkin signaling pathway and miR-34a expression.
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              Text: 2026 Jun 11
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