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Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT.

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Title: Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT.
Authors: Baysoy A; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Tian X; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Renauer P; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Zhang F; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Bai Z; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Shi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang M; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Zhang D; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Liu M; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Li H; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Tao B; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Enninful A; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Lu Y; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Gao F; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Wang G; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Zhang W; Aspect Analytics, Genk, Belgium., Tran T; Aspect Analytics, Genk, Belgium., Patterson NH; Aspect Analytics, Genk, Belgium., Sheng J; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA., Bao S; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Dong C; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Xin S; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Chen B; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Zhong M; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Cell Biology, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA., Rankin S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Guy C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang Y; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Connelly JP; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang D; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA., Xu M; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Gerstein MB; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Chi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen S; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu.; Systems Biology Institute, Integrated Science and Technology Center, West Haven, CT, USA. sidi.chen@yale.edu.; Yale Stem Cell Center and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu., Fan R; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. rong.fan@yale.edu.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.; Systems Biology Institute, Integrated Science and Technology Center, West Haven, CT, USA. rong.fan@yale.edu.; Yale Stem Cell Center and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.; Human and Translational Immunology, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Baysoy+A%22">Baysoy A</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Renauer+P%22">Renauer P</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Bai+Z%22">Bai Z</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; 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Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+M%22">Zhong M</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Department of Cell Biology, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Rankin+S%22">Rankin S</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Guy+C%22">Guy C</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Connelly+JP%22">Connelly JP</searchLink>; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pruett-Miller+SM%22">Pruett-Miller SM</searchLink>; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Gerstein+MB%22">Gerstein MB</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Chi+H%22">Chi H</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu.; Systems Biology Institute, Integrated Science and Technology Center, West Haven, CT, USA. sidi.chen@yale.edu.; Yale Stem Cell Center and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu.<br /><searchLink fieldCode="AU" term="%22Fan+R%22">Fan R</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. rong.fan@yale.edu.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.; Systems Biology Institute, Integrated Science and Technology Center, West Haven, CT, USA. rong.fan@yale.edu.; Yale Stem Cell Center and Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.; Human and Translational Immunology, Yale University School of Medicine, New Haven, CT, USA. rong.fan@yale.edu.
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